Piercy K T, Myers R D
Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Physiol Behav. 1995 Jun;57(6):1155-61. doi: 10.1016/0031-9384(95)00026-f.
Although the hamster generally prefers alcohol at a level similar to that of the rat or mouse selectively bred to consume alcohol, the drinking hamster demonstrates neither physical dependence on alcohol nor elevated blood levels of alcohol, which are two typical criteria characterizing an animal model of alcoholism. The present investigation was designed to determine whether a third criterion of an animal model (i.e., consumption of high levels of alcohol in the presence of a palatable fluid, fulfilled by the P rat) would be met by the female Syrian golden hamster (Mesocricetus auratus). A standard 3-bottle preference test was undertaken in 6 female hamsters over an 11 day period, in which water was presented in one tube and, in a second tube, a v/v solution of alcohol which was increased in concentration from 3% to 50% on each day as follows: 3%, 5%, 7%, 9%, 12%, 15%, 20%, 25%, 30%, 40%, and 50%. Then each hamster was offered its individually determined, maximally preferred concentration of alcohol for 4-8 days, which was 20%, 25%, or 30% alcohol. The mean absolute intake of alcohol during this period was 17.9 +/- 1.1 g/kg per day, whereas the mean proportion of alcohol to total fluid was 0.68 +/- 0.05. Then over a 4-day interval, a solution of tomato juice, peach juice, mango juice, dextrose and a chocolate beverage (Ensure Plus), all made isocaloric to the alcohol solutions with dextrose, was placed in the third tube simultaneously with water and the individually preferred concentration of alcohol.(ABSTRACT TRUNCATED AT 250 WORDS)
虽然仓鼠通常在与选择性培育以摄入酒精的大鼠或小鼠相似的水平上更喜欢酒精，但饮酒的仓鼠既没有对酒精产生身体依赖，血液中的酒精水平也没有升高，而这是酒精中毒动物模型的两个典型标准。本研究旨在确定雌性叙利亚金仓鼠（Mesocricetus auratus）是否满足动物模型的第三个标准（即，在有美味液体的情况下摄入高水平酒精，P大鼠满足此标准）。对6只雌性仓鼠进行了为期11天的标准三瓶偏好测试，其中一根管子里装水，另一根管子里装酒精的v/v溶液，酒精浓度每天从3%增加到50%，如下所示：3%、5%、7%、9%、12%、15%、20%、25%、30%、40%和50%。然后给每只仓鼠提供其各自确定的、最偏好的酒精浓度，持续4至8天，该浓度为20%、25%或30%的酒精。在此期间，酒精的平均绝对摄入量为每天17.9±1.1克/千克，而酒精占总液体的平均比例为0.68±0.05。然后在4天的间隔内，将番茄汁、桃汁、芒果汁、葡萄糖和巧克力饮料（安素益加）的溶液与水和各自偏好的酒精浓度同时放入第三根管子中，所有这些溶液都用葡萄糖制成与酒精溶液等热量。（摘要截断于250字）
