• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport.

作者信息

Oude Elferink R P, Meijer D K, Kuipers F, Jansen P L, Groen A K, Groothuis G M

机构信息

Department of Gastrointestinal and Liver Diseases, Academic Medical Center, AZ Amsterdam, The Netherlands.

出版信息

Biochim Biophys Acta. 1995 Jul 17;1241(2):215-68. doi: 10.1016/0304-4157(95)00006-d.

DOI:10.1016/0304-4157(95)00006-d
PMID:7640297
Abstract
摘要

相似文献

1
Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport.肝脏对有机化合物的分泌；膜转运的分子机制。
Biochim Biophys Acta. 1995 Jul 17;1241(2):215-68. doi: 10.1016/0304-4157(95)00006-d.
2
The molecular basis for hepatobiliary transport of organic cations and organic anions.
Pharm Biotechnol. 1999;12:89-157. doi: 10.1007/0-306-46812-3_4.
3
[Hepatobiliary regulation of lipid metabolism].
Schweiz Med Wochenschr. 1970 Oct 3;100(40):1694-8.
4
Molecular aspects of bile formation and cholestasis.胆汁形成与胆汁淤积的分子机制
Trends Mol Med. 2003 Dec;9(12):558-64. doi: 10.1016/j.molmed.2003.10.002.
5
Hepatobiliary transport of bile acids and organic anions.胆汁酸和有机阴离子的肝胆转运
J Hepatobiliary Pancreat Surg. 2002;9(4):443-7. doi: 10.1007/s005340200055.
6
A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule.肝脏小叶胆汁流体动力学的预测性三维多尺度模型。
Cell Syst. 2017 Mar 22;4(3):277-290.e9. doi: 10.1016/j.cels.2017.02.008. Epub 2017 Mar 18.
7
Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver.牛磺熊去氧胆酸将顶端结合物输出泵Mrp2插入胆小管膜，并通过蛋白激酶C依赖性机制刺激胆汁淤积大鼠肝脏中的有机阴离子分泌。
Hepatology. 2001 May;33(5):1206-16. doi: 10.1053/jhep.2001.24034.
8
Mechanism of the tissue distribution and biliary excretion of the cyclic peptide octreotide.环肽奥曲肽的组织分布及胆汁排泄机制
J Pharmacol Exp Ther. 1996 Dec;279(3):1357-64.
9
Bile secretory function in the obese Zucker rat: evidence of cholestasis and altered canalicular transport function.肥胖型 Zucker 大鼠的胆汁分泌功能：胆汁淤积及胆小管转运功能改变的证据。
Gut. 2004 Dec;53(12):1837-43. doi: 10.1136/gut.2003.037689.
10
PET imaging-based evaluation of hepatobiliary transport in humans with (15R)-11C-TIC-Me.基于 (15R)-11C-TIC-Me 的正电子发射断层扫描成像评估人类肝胆转运。
J Nucl Med. 2012 May;53(5):741-8. doi: 10.2967/jnumed.111.098681. Epub 2012 Apr 12.

引用本文的文献

1
The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review.ABCBl、ABCC2 和 RALBP1 多态性与癫痫患者卡马西平反应相关：系统评价。
Acta Neurol Belg. 2022 Aug;122(4):871-880. doi: 10.1007/s13760-022-01920-5. Epub 2022 Mar 24.
2
Metabolism and disposition of oseltamivir (OS) in rats, determined by immunohistochemistry with monospecific antibody for OS or its active metabolite oseltamivir carboxylate (OC): A possibility of transporters dividing the drugs' excretion into the bile and kidney.奥司他韦（OS）在大鼠体内的代谢和处置，通过针对 OS 或其活性代谢物奥司他韦羧酸（OC）的单特异性抗体进行免疫组织化学来确定：一种可能是转运蛋白将药物的排泄分为胆汁和肾脏。
Pharmacol Res Perspect. 2020 Jun;8(3):e00597. doi: 10.1002/prp2.597.
3
Glucuronidation as a metabolic barrier against zearalenone in rat everted intestine.葡萄糖醛酸化作为大鼠外翻肠中玉米赤霉烯酮的代谢屏障。
J Vet Med Sci. 2020 Feb 4;82(2):153-161. doi: 10.1292/jvms.19-0570. Epub 2019 Dec 16.
4
Effects of Red Ginseng Extract on the Pharmacokinetics and Elimination of Methotrexate via Mrp2 Regulation.红参提取物通过调节 MRP2 对甲氨蝶呤药代动力学和消除的影响。
Molecules. 2018 Nov 12;23(11):2948. doi: 10.3390/molecules23112948.
5
Ursodeoxycholate Restores Biliary Excretion of Methotrexate in Rats with Ethinyl Estradiol Induced-Cholestasis by Restoring Canalicular Mrp2 Expression.熊去氧胆酸通过恢复胆小管多药耐药相关蛋白 2 表达恢复雌二醇诱导的胆汁淤积大鼠的甲氨蝶呤胆汁排泄。
Int J Mol Sci. 2018 Apr 9;19(4):1120. doi: 10.3390/ijms19041120.
6
Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats.Jaspine B 的药代动力学及其在胆汁酸存在下在大鼠体内的肠吸收增强作用。
Mar Drugs. 2017 Sep 1;15(9):279. doi: 10.3390/md15090279.
7
Renal Drug Transporters and Drug Interactions.肾脏药物转运体与药物相互作用
Clin Pharmacokinet. 2017 Aug;56(8):825-892. doi: 10.1007/s40262-017-0506-8.
8
Increased Renal Clearance of Rocuronium Compensates for Chronic Loss of Bile Excretion, via upregulation of Oatp2.罗库溴铵经肾脏清除增加，通过上调 Oatp2 代偿慢性胆汁排泄损失。
Sci Rep. 2017 Jan 13;7:40438. doi: 10.1038/srep40438.
9
Colorectal cancers and chlorinated water.结直肠癌与氯化水
World J Gastrointest Oncol. 2016 Apr 15;8(4):402-9. doi: 10.4251/wjgo.v8.i4.402.
10
Spheroid culture for enhanced differentiation of human embryonic stem cells to hepatocyte-like cells.球体培养法增强人胚胎干细胞向肝细胞样细胞的分化。
Stem Cells Dev. 2014 Jan 15;23(2):124-31. doi: 10.1089/scd.2013.0097. Epub 2013 Oct 22.