El-Tawil Ahmed Mahmoud
Ahmed Mahmoud El-Tawil, Department of Surgery, University Hospital Birmingham, Birmingham B15 2GW, United Kingdom.
World J Gastrointest Oncol. 2016 Apr 15;8(4):402-9. doi: 10.4251/wjgo.v8.i4.402.
Published reports have revealed increased risk of colorectal cancers in people exposed to chlorinated drinking water or chemical derivatives of chlorination. Oestrogen plays a dual positive functions for diminishing the possibilities of such risk by reducing the entrance, and increasing the excretion, of these chemicals. In addition, there are supplementary measures that could be employed in order to reduce this risk further, such as boiling the drinking water, revising the standard concentrations of calcium, magnesium and iron in the public drinking water and prescribing oestrogen in susceptible individuals. Hypo-methylation of genomic DNA could be used as a biological marker for screening for the potential development of colorectal cancers.
已发表的报告显示，接触氯化饮用水或氯化化学衍生物的人群患结直肠癌的风险增加。雌激素具有双重积极作用，通过减少这些化学物质的摄入并增加其排泄，降低此类风险发生的可能性。此外，还可以采取补充措施进一步降低这种风险，例如煮沸饮用水、调整公共饮用水中钙、镁和铁的标准浓度，以及对易感个体开具雌激素处方。基因组DNA的低甲基化可作为筛查结直肠癌潜在发展的生物学标志物。
