Mouse protection induced by Pseudomonas aeruginosa PAC1R and its defective mutants, Salmonella minnesota Re-mutant and Escherichia coli O14.

作者信息

Stanislavsky E S, Kholodkova E V, Makarenko T A, Sukhachevskaya M V

机构信息

II. Mechnicov Research Institute for Vaccine and Sera, Russian Academy of Medical Sciences, Moscow.

出版信息

FEMS Immunol Med Microbiol. 1995 Apr;11(2):81-6. doi: 10.1111/j.1574-695X.1995.tb00092.x.

Pseudomonas aeruginosa PAC1R and its defective mutants (acetone-killed bacteria), Salmonella minnesota Re mutant (acetone-killed bacteria and Re-LPS) and Escherichia coli O14 (acetone-killed bacteria and enterobacterial common antigen, ECA) were studied in a mouse active protection test. Immunized mice were challenged with wild-type P. aeruginosa strains. It was established that P. aeruginosa LPS-defective mutants induced cross-immunity against different Fisher immunotypes of P. aeruginosa. S. minnesota Re-LPS and ECA gave mice protection against P. aeruginosa.