用明尼苏达沙门氏菌R突变株进行免疫接种。II. 脂质A免疫接种与Re突变株保护效果的比较。
Immunization with R mutants of Salmonella minnesota. II. Comparison of the protective effect of immunization with lipid A and the Re mutant.
作者信息
Bruins S C, Stumacher R, Johns M A, McCabe W R
出版信息
Infect Immun. 1977 Jul;17(1):16-20. doi: 10.1128/iai.17.1.16-20.1977.
Abstract
The protective effect of active immunization with Salmonella minnesota Re bacilli or lipid A was assessed in the granulocytopenic rabbit model. Animals were immunized with Re bacilli, lipid A, or Pseudomonas aeruginosa as a nonspecific immunogen. After colonization with one of three enterobacterial strains (two Escherichia coli, one Enterobacter aerogenes), the immunized rabbits as well as controls given saline injections were made leukopenic with nitrogen mustard and monitored for fever, bacteremia, and death. Survival rates were significantly greater in Re-immunized animals than in saline controls or P. aeruginosa-immunized animals. Immunization with lipid A afforded no protection. In addition, rabbits immunized with Re mutant bacilli developed bacteremia less frequently than the others, indicating that antibody to Re may inhibit invasion of the intestinal mucosa as well as protect after bacteremia has developed.
摘要
在粒细胞减少的兔模型中评估了用明尼苏达沙门氏菌Re杆菌或脂多糖进行主动免疫的保护作用。动物分别用Re杆菌、脂多糖或铜绿假单胞菌作为非特异性免疫原进行免疫。在用三种肠杆菌菌株之一（两种大肠杆菌、一种产气肠杆菌）定殖后，用氮芥使免疫的兔子以及接受盐水注射的对照动物出现白细胞减少，并监测发热、菌血症和死亡情况。Re免疫动物的存活率显著高于盐水对照或铜绿假单胞菌免疫动物。用脂多糖免疫没有提供保护作用。此外，用Re突变杆菌免疫的兔子发生菌血症的频率低于其他兔子，这表明针对Re的抗体可能抑制肠道黏膜的侵袭以及在菌血症发生后提供保护。
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