Chavassieux P, Meunier P J
Inserm, unité 403, faculté Alexis-Carrel, Lyon, France.
Arch Pediatr. 1995 Jun;2(6):568-72. doi: 10.1016/0929-693x(96)81203-6.
Fluoride is an essential trace element. It is incorporated in calcified tissues. At doses lower than 1.5 mg/day, fluoride has a prophylactic action against dental caries by absorption on the enamel surface. At doses ranging from 15 to 25 mg/day, it is used as a therapeutic agent in adults, in the treatment of post-menopausal osteoporosis with vertebral crush fractures. At high doses, fluoride may induce skeletal fluorosis leading in children to pseudorachitism. In children, fluoride supplement has been recommended for several years, as a prophylactic agent against dental caries. It may be given either as dentifrices and toothwash solutions, easy to use and economic but contraindicated in very young children; or as tablets, sure and effective but requiring a daily intake; or as domestic salts supplemented with 250 mg/kg. Fluoride supplement may also be given through drinking water. Fluoride content is limited to 1.5 mg/l but some mineral waters contain high amounts of fluoride and may have a beneficial effect on bone mass. In order to prevent an excessive fluoride intake in children and in adults, different forms of fluoride supplements must not be associated.
氟是一种必需的微量元素。它被纳入钙化组织中。当剂量低于1.5毫克/天时,氟通过在牙釉质表面吸收对龋齿具有预防作用。当剂量在15至25毫克/天时,它被用作成人的治疗剂,用于治疗伴有椎体压缩性骨折的绝经后骨质疏松症。高剂量时,氟可能会导致骨骼氟中毒,在儿童中会导致假性佝偻病。多年来,一直建议给儿童补充氟,作为预防龋齿的药剂。它可以以牙膏和漱口水的形式给药,使用方便且经济,但非常年幼的儿童禁用;也可以以片剂形式给药,可靠且有效,但需要每日服用;或者作为每千克补充250毫克氟的家用盐。氟补充剂也可以通过饮用水给予。氟含量限制在1.5毫克/升,但一些矿泉水中含有大量的氟,可能对骨量有有益影响。为了防止儿童和成人摄入过量的氟,不同形式的氟补充剂不得同时使用。