铅作为大鼠脑突触体某些形态和功能变化的诱导剂。
Lead as an inductor of some morphological and functional changes in synaptosomes from rat brain.
作者信息
Jabłońska L, Walski M, Rafałowska U
机构信息
Department of Neurochemistry, Polish Academy of Sciences, Warsaw.
出版信息
Cell Mol Neurobiol. 1994 Dec;14(6):701-9. doi: 10.1007/BF02088678.
Abstract
- The effect of lead (in vivo) on the uptake of GABA, dopamine, and histidine as a precursor of histamine in synaptosomes obtained from chronically lead-treated rats was studied. 2. Lead decreased the uptake of GABA, increased the uptake of dopamine, and did not change the uptake of histidine. These effects were independent of calcium concentration. 3. Lead administration to the rat changed the morphology of the synaptosomes, as manifested in the decreased number of synaptic vesicles and disturbed mitochondrial structure. 4. The results suggest the existence of several mechanisms of lead toxicity on uptake, related to individual neurotransmitters, which are not necessarily connected with a Pb2+/Ca2+ interaction.
摘要
- 研究了铅（体内）对从长期铅处理大鼠获得的突触体中γ-氨基丁酸（GABA）、多巴胺以及作为组胺前体的组氨酸摄取的影响。2. 铅降低了GABA的摄取，增加了多巴胺的摄取，并且未改变组氨酸的摄取。这些效应与钙浓度无关。3. 给大鼠施用铅改变了突触体的形态，表现为突触小泡数量减少和线粒体结构紊乱。4. 结果表明存在几种铅对摄取产生毒性的机制，这些机制与单个神经递质有关，不一定与Pb2+/Ca2+相互作用相关。
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