Thomsen L L, Iversen H K, Olesen J
Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
Cephalalgia. 1995 Apr;15(2):109-16. doi: 10.1046/j.1468-2982.1995.015002109.x.
It has been disputed whether or not large intracranial arteries are dilated during migraine attacks. In order to answer this question the present transcranial Doppler study focused on side-to-side differences of middle cerebral artery blood velocity during unilateral attacks of migraine without aura in 25 patients. Blood velocity in the middle cerebral artery was lower on the headache side (59 cm/s) than on the non-headache side (65 cm/s) during the migraine attack. No such difference was found outside of attack (65 cm/s both sides). The difference (headache side minus non-headache side) was on average -6.1 cm/s during attack compared to -0.4 cm/s outside of attack (p = 0.01). Assuming that rCBF is unchanged during attacks of migraine without aura, our results suggest a 9% increase in middle cerebral artery lumen (cross-sectional area) on the affected side during unilateral attacks of migraine without aura. The findings, however, do not necessarily mean that arterial dilatation is the only or even the most significant cause of pain.
在偏头痛发作期间颅内大血管是否会扩张一直存在争议。为了回答这个问题，目前的经颅多普勒研究聚焦于25例无先兆偏头痛单侧发作时大脑中动脉血流速度的双侧差异。在偏头痛发作期间，头痛侧大脑中动脉的血流速度（59厘米/秒）低于非头痛侧（65厘米/秒）。在发作间期未发现这种差异（双侧均为65厘米/秒）。发作期间差异（头痛侧减去非头痛侧）平均为-6.1厘米/秒，而发作间期为-0.4厘米/秒（p = 0.01）。假设在无先兆偏头痛发作期间局部脑血流量不变，我们的结果表明在无先兆偏头痛单侧发作期间，患侧大脑中动脉管腔（横截面积）增加9%。然而，这些发现并不一定意味着动脉扩张是疼痛的唯一甚至是最主要原因。
