van Helvoort A, van Meer G
Department of Cell Biology, Faculty of Medicine, Universiteit Utrecht, The Netherlands.
FEBS Lett. 1995 Aug 1;369(1):18-21. doi: 10.1016/0014-5793(95)00616-h.
The differences in lipid composition between intracellular membranes cannot be adequately explained by local synthesis and degradation. Especially in the case of sphingolipids, which are synthesized in the Golgi complex but enriched on the cell surface and in endocytotic organelles, there is evidence for a cellular machinery that preferentially shuttles these lipids in vesicles to the cell surface. The machinery appears to involve the formation of domains of sphingolipid and cholesterol in the lumenal leaflet of Golgi membranes. Several pieces of evidence suggest that the selective anterograde transport of plasma membrane proteins may be mechanistically related to the sphingolipid domains.
细胞内膜之间脂质组成的差异无法通过局部合成和降解得到充分解释。特别是鞘脂的情况，它们在高尔基体复合体中合成，但在细胞表面和内吞细胞器中富集，有证据表明存在一种细胞机制，可优先将这些脂质通过囊泡转运到细胞表面。该机制似乎涉及高尔基体膜腔面膜小叶中鞘脂和胆固醇结构域的形成。几条证据表明，质膜蛋白的选择性顺向转运可能在机制上与鞘脂结构域相关。
