Batista M C, Cartledge T P, Zellmer A W, Merino M J, Axiotis C, Bremner W J, Nieman L K
National Institute of Child Health and Human Development, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
Fertil Steril. 1995 Sep;64(3):492-9.
To investigate changes in menstrual cycle hormones and endometrial maturation that may contribute to the decline in fertility with aging.
Prospective controlled clinical study.
Normal human volunteers in an academic research institution.
Women with regular menstrual cycles.
Thirty-two women, aged 20 to 30 or 40 to 50 years, had daily blood drawing starting on cycle day 6 to 10 and continuing until 2 days after the onset of next menses. In addition, 60 women, aged 20 to 30 or 40 to 50 years, had a total of 93 endometrial biopsies performed on day 7 to 9 after the LH surge.
Serum LH, FSH, E2, inhibin, P, and placental protein 14 (PP14) levels and histologic maturation of the endometrium.
Serum FSH levels were increased whereas inhibin concentrations were reduced in the luteal-follicular transition of women > 40 years. No other hormonal changes were seen in this population, including P and PP14 secretion. Disruption of endometrial maturation occurred at a similar frequency in both age groups.
Follicular recruitment, but not luteal function or endometrial maturation, is disturbed in cycling women > 40 years and may contribute to the decline in fertility with aging.
研究月经周期激素和子宫内膜成熟度的变化，这些变化可能导致随着年龄增长生育能力下降。
前瞻性对照临床研究。
一所学术研究机构中的正常人类志愿者。
月经周期规律的女性。
32名年龄在20至30岁或40至50岁的女性，从月经周期第6至10天开始每日采血，持续至下次月经来潮后2天。此外，60名年龄在20至30岁或40至50岁的女性，在促黄体生成素（LH）峰出现后的第7至9天共进行了93次子宫内膜活检。
血清促黄体生成素（LH）、促卵泡生成素（FSH）、雌二醇（E2）、抑制素、孕酮（P）和胎盘蛋白14（PP14）水平以及子宫内膜的组织学成熟度。
40岁以上女性在黄体 - 卵泡过渡期血清FSH水平升高，而抑制素浓度降低。该人群未观察到其他激素变化，包括孕酮和PP14分泌。两个年龄组子宫内膜成熟度的破坏发生率相似。
40岁以上处于月经周期的女性卵泡募集受到干扰，但黄体功能或子宫内膜成熟度未受影响，这可能导致随着年龄增长生育能力下降。
