一种与哺乳动物巨噬细胞炎性蛋白-1β同源的新型鸡趋化因子编码cDNA的分离。
Isolation of a cDNA encoding a novel chicken chemokine homologous to mammalian macrophage inflammatory protein-1 beta.
作者信息
Petrenko O, Ischenko I, Enrietto P J
机构信息
Department of Microbiology, State University of New York at Stony Brook 11794, USA.
出版信息
Gene. 1995 Jul 28;160(2):305-6. doi: 10.1016/0378-1119(95)00210-w.
A cDNA encoding a novel chicken chemokine homologous to mammalian chemokine macrophage inflammatory protein 1 beta (MIP-1 beta) was isolated and characterised. The cDNA encodes a protein which is 75-80% homologous to human and mouse MIP-1 beta. All conserved amino acids characteristic of the mammalian chemokine family have been evolutionarily preserved in chicken MIP-1 beta, suggesting similar protein folding patterns and functional properties.
分离并鉴定了一种与哺乳动物趋化因子巨噬细胞炎性蛋白1β（MIP-1β）同源的新型鸡趋化因子的cDNA。该cDNA编码的蛋白质与人和小鼠的MIP-1β具有75%-80%的同源性。哺乳动物趋化因子家族所有保守的氨基酸特征在鸡MIP-1β中都得到了进化上的保留，这表明它们具有相似的蛋白质折叠模式和功能特性。
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