Yoshida T, Imai T, Kakizaki M, Nishimura M, Yoshie O
Shionogi Institute for Medical Science, Osaka, Japan.
FEBS Lett. 1995 Feb 27;360(2):155-9. doi: 10.1016/0014-5793(95)00093-o.
From human PBMC stimulated with PHA, we have isolated cDNA clones encoding a novel cytokine named SCM-1, which is significantly related to the CC and the CXC chemokines but has only the 2nd and the 4th of the four cysteines conserved in these proteins. Its gene is also distinctly mapped to human chromosome 1. SCM-1 is strongly induced in human PBMC and Jurkat T cells by PHA stimulation. Among various human tissues, SCM-1 is expressed most strongly in spleen. SCM-1 is found to be 60.5% identical to lymphotactin, a recently described murine lymphocyte-specific chemokine, which also retains only two cysteines. SCM-1 and lymphotactin may thus represent the human and murine prototypes of a novel C or gamma type chemokine family.
从用PHA刺激的人外周血单核细胞（PBMC）中，我们分离出了编码一种名为SCM-1的新型细胞因子的cDNA克隆，该细胞因子与CC和CXC趋化因子显著相关，但在这些蛋白质中仅保留了四个半胱氨酸中的第二个和第四个。其基因也明确定位于人类1号染色体。SCM-1在PHA刺激下在人PBMC和Jurkat T细胞中强烈诱导表达。在各种人体组织中，SCM-1在脾脏中表达最强。发现SCM-1与淋巴细胞趋化因子有60.5%的同源性，淋巴细胞趋化因子是最近描述的一种小鼠淋巴细胞特异性趋化因子，也仅保留两个半胱氨酸。因此，SCM-1和淋巴细胞趋化因子可能代表了一个新型C或γ型趋化因子家族的人类和小鼠原型。
