Kozak C A, Gao J L, Murphy P M
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Genomics. 1995 Sep 1;29(1):294-6. doi: 10.1006/geno.1995.1250.
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) and RANTES are members of the beta chemokine family of leukocyte chemoattractants. We have previously cloned three mouse genes by cross-hybridization with the human MIP-1 alpha/RANTES receptor gene CMKBR1. One of the mouse genes, Scya3r, encodes a functional MIP-1 alpha receptor. The functions of the other two, Scya3r-rs1 and Scya3r-rs2, are not known. We have now mapped Scya3r, Scya3r-rs1, and Scya3r-rs2 to chromosome 9, in a region of conserved synteny with the location of CMKBR1. Thus, like chemokine genes and alpha chemokine receptor genes, this group of beta chemokine receptor genes arose by tandem duplication.
巨噬细胞炎性蛋白-1α（MIP-1α）和调节激活正常T细胞表达和分泌因子（RANTES）是白细胞趋化因子β趋化因子家族的成员。我们之前通过与人MIP-1α/RANTES受体基因CMKBR1交叉杂交克隆了三个小鼠基因。其中一个小鼠基因Scya3r编码一种功能性MIP-1α受体。另外两个基因Scya3r-rs1和Scya3r-rs2的功能尚不清楚。我们现已将Scya3r、Scya3r-rs1和Scya3r-rs2定位到9号染色体上，该区域与CMKBR1的位置存在保守的同线性。因此，与趋化因子基因和α趋化因子受体基因一样，这组β趋化因子受体基因是通过串联重复产生的。
