1H NMR investigation of the interaction of berberine and sanguinarine with DNA.
作者信息
Saran A, Srivastava S, Coutinho E, Maiti M
机构信息
Chemical Physics Group, Tata Institute of Fundamental Research, Colaba, Bombay.
出版信息
Indian J Biochem Biophys. 1995 Apr;32(2):74-7.
PMID:7642203
Abstract
Interaction of the alkaloids, berberine and sanguinarine with calf thymus DNA has been studied by 1H NMR. All proton resonances of the two compounds have been assigned using 2D-COSY, NOESY and ROESY spectra. Berberine has been found to partially intercalate into DNA, while sanguinarine shows normal intercalation and also binds more firmly to DNA. The NMR experiments indicate that sanguinarine is more potent than berberine in its activity.
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