眼镜蛇毒因子消除了仓鼠对梅毒感染的被动体液抵抗力。
Cobra venom factor abrogates passive humoral resistance to syphilitic infection in hamsters.
作者信息
Azadegan A A, Tabor D R, Schell R F, LeFrock J L
出版信息
Infect Immun. 1984 Jun;44(3):740-2. doi: 10.1128/iai.44.3.740-742.1984.
Abstract
Cobra venom factor, an agent commonly used to deplete complement, lowered the resistance of hamsters to infection with Treponema pallidum subsp. endemicum , as shown by a more rapid development of cutaneous lesions in infected animals treated with cobra venom factor than in infected, untreated animals. Cobra venom factor also abrogated the passive transfer of resistance by injection of serum from syphilitic immune hamsters. These results indicate that complement influences the pathogenesis of treponemal infection.
摘要
眼镜蛇毒因子是一种常用于消耗补体的制剂，它降低了仓鼠对地方亚种梅毒螺旋体感染的抵抗力，这表现为在用眼镜蛇毒因子治疗的感染动物中，皮肤损伤的发展比未治疗的感染动物更快。眼镜蛇毒因子还通过注射来自梅毒免疫仓鼠的血清消除了抵抗力的被动转移。这些结果表明补体影响梅毒螺旋体感染的发病机制。
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A comparison of cobra venom factor-induced depletion of serum C3 in eight different strains of mice.八种不同品系小鼠中眼镜蛇毒因子诱导的血清C3消耗的比较。
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