补体的消耗及其对伯氏疏螺旋体感染抵抗力被动转移的影响。
Depletion of complement and effects on passive transfer of resistance to infection with Borrelia burgdorferi.
作者信息
Schmitz J L, Lovrich S D, Callister S M, Schell R F
机构信息
Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison 53706.
出版信息
Infect Immun. 1991 Oct;59(10):3815-8. doi: 10.1128/iai.59.10.3815-3818.1991.
Abstract
When irradiated hamsters are passively immunized with immune serum before challenge with Borrelia burgdorferi, they are completely protected from arthritis and infection. The complement dependency of this protection was addressed by treating hamsters with cobra venom factor. Depletion of complement abrogated the ability of immune serum obtained 1 and 10 weeks after infection to confer complete protection. By contrast, depletion of complement had no effect on the ability of 3-week immune serum to confer protection. These results suggest that complement-dependent, and possibly complement-independent, antibodies are important for preventing the induction of Lyme arthritis.
摘要
在用伯氏疏螺旋体攻击之前，给受辐照的仓鼠被动注射免疫血清，它们可完全免受关节炎和感染。通过用眼镜蛇毒因子处理仓鼠来研究这种保护作用对补体的依赖性。补体耗竭消除了感染后1周和10周获得的免疫血清提供完全保护的能力。相比之下，补体耗竭对3周龄免疫血清的保护能力没有影响。这些结果表明，补体依赖性抗体以及可能的非补体依赖性抗体对于预防莱姆关节炎的诱导很重要。
相似文献
1
Depletion of complement and effects on passive transfer of resistance to infection with Borrelia burgdorferi.补体的消耗及其对伯氏疏螺旋体感染抵抗力被动转移的影响。
Infect Immun. 1991 Oct;59(10):3815-8. doi: 10.1128/iai.59.10.3815-3818.1991.
2
Immunoglobulin G2 confers protection against Borrelia burgdorferi infection in LSH hamsters.免疫球蛋白G2赋予LSH仓鼠抵抗伯氏疏螺旋体感染的能力。
Infect Immun. 1992 Jul;60(7):2677-82. doi: 10.1128/iai.60.7.2677-2682.1992.
3
Isolation of moderately infectious Borrelia burgdorferi sensu stricto from attenuated cultures by using complement-mediated, antibody-dependent lysis selection technique in a mammalian tissue co-culture system.在哺乳动物组织共培养系统中，通过使用补体介导的抗体依赖性裂解选择技术，从减毒培养物中分离出中度传染性的狭义伯氏疏螺旋体。
Microbes Infect. 2003 Aug;5(10):869-78. doi: 10.1016/s1286-4579(03)00178-3.
4
Passive immunization prevents induction of Lyme arthritis in LSH hamsters.被动免疫可预防LSH仓鼠发生莱姆关节炎。
Infect Immun. 1990 Jan;58(1):144-8. doi: 10.1128/iai.58.1.144-148.1990.
5
Cobra venom factor abrogates passive humoral resistance to syphilitic infection in hamsters.眼镜蛇毒因子消除了仓鼠对梅毒感染的被动体液抵抗力。
Infect Immun. 1984 Jun;44(3):740-2. doi: 10.1128/iai.44.3.740-742.1984.
6
Passive immunization of hamsters against experimental infection with the Lyme disease spirochete.用莱姆病螺旋体对仓鼠进行被动免疫以抵抗实验性感染。
Infect Immun. 1986 Sep;53(3):713-4. doi: 10.1128/iai.53.3.713-714.1986.
7
Borreliacidal activity of sera from hamsters infected with the Lyme disease spirochete.感染莱姆病螺旋体的仓鼠血清的杀疏螺旋体活性。
Infect Immun. 1991 Aug;59(8):2522-8. doi: 10.1128/iai.59.8.2522-2528.1991.
8
Complement evasion by the Lyme disease spirochete Borrelia burgdorferi grown in host-derived tissue co-cultures: role of fibronectin in complement-resistance.在宿主来源组织共培养物中生长的莱姆病螺旋体伯氏疏螺旋体对补体的逃避：纤连蛋白在补体抗性中的作用
Experientia. 1996 Apr 15;52(4):364-72. doi: 10.1007/BF01919542.
9
Decomplementation by cobra venom factor suppresses Yersinia-induced arthritis in rats.眼镜蛇毒因子介导的补体灭活可抑制大鼠耶尔森菌诱导的关节炎。
Infect Immun. 1995 Sep;63(9):3697-701. doi: 10.1128/iai.63.9.3697-3701.1995.
10
Serum-mediated resolution of Lyme arthritis in mice.血清介导的小鼠莱姆关节炎的消退
Lab Invest. 1996 Jan;74(1):57-67.
引用本文的文献
1
A Structural Basis for Inhibition of the Complement Initiator Protease C1r by Lyme Disease Spirochetes.莱姆病螺旋体抑制补体起始蛋白酶 C1r 的结构基础。
J Immunol. 2021 Dec 1;207(11):2856-2867. doi: 10.4049/jimmunol.2100815. Epub 2021 Nov 10.
2
Complement Evasion by Lyme Disease Spirochetes.莱姆病螺旋体的补体逃避。
Trends Microbiol. 2020 Nov;28(11):889-899. doi: 10.1016/j.tim.2020.05.004. Epub 2020 May 29.
3
The Classical Complement Pathway Is Required to Control Levels During Experimental Infection.经典补体途径是控制实验感染期间水平所必需的。
Front Immunol. 2018 May 7;9:959. doi: 10.3389/fimmu.2018.00959. eCollection 2018.
4
Effect of complement component C3 deficiency on experimental Lyme borreliosis in mice.补体成分C3缺乏对小鼠实验性莱姆病的影响。
Infect Immun. 2003 Aug;71(8):4432-40. doi: 10.1128/IAI.71.8.4432-4440.2003.
5
Gamma interferon inhibits production of Anti-OspA borreliacidal antibody in vitro.γ干扰素在体外抑制抗OspA杀疏螺旋体抗体的产生。
Clin Diagn Lab Immunol. 2002 Sep;9(5):1095-101. doi: 10.1128/cdli.9.5.1095-1101.2002.
6
Modulation of murine Lyme borreliosis by interruption of the B7/CD28 T-cell costimulatory pathway.通过中断B7/CD28 T细胞共刺激途径对小鼠莱姆病的调节
Infect Immun. 1998 Jan;66(1):266-71. doi: 10.1128/IAI.66.1.266-271.1998.
7
Complement-mediated serum sensitivity among spirochetes that cause Lyme disease.引起莱姆病的螺旋体中补体介导的血清敏感性。
Infect Immun. 1997 Apr;65(4):1228-36. doi: 10.1128/iai.65.4.1228-1236.1997.
8
Early and early disseminated phases of Lyme disease in the rhesus monkey: a model for infection in humans.恒河猴莱姆病的早期和早期播散阶段：人类感染的模型
Infect Immun. 1993 Jul;61(7):3047-59. doi: 10.1128/iai.61.7.3047-3059.1993.
9
Borrelia burgdorferi infection and immunity in mice deficient in the fifth component of complement.补体第五成分缺陷小鼠中的伯氏疏螺旋体感染与免疫
Infect Immun. 1993 May;61(5):2104-7. doi: 10.1128/iai.61.5.2104-2107.1993.
10
Passive immunizing activity of sera from mice infected with Borrelia burgdorferi.感染伯氏疏螺旋体的小鼠血清的被动免疫活性。
Infect Immun. 1993 Nov;61(11):4696-702. doi: 10.1128/iai.61.11.4696-4702.1993.
本文引用的文献
1
In vivo evidence that an intact lytic complement pathway is not essential for successful removal of circulating Borrelia turicatae from mouse blood.体内证据表明，完整的溶细胞补体途径对于从小鼠血液中成功清除循环的杜氏疏螺旋体并非必不可少。
Infect Immun. 1981 Jan;31(1):465-9. doi: 10.1128/iai.31.1.465-469.1981.
2
The spirochetal etiology of Lyme disease.莱姆病的螺旋体病因
N Engl J Med. 1983 Mar 31;308(13):733-40. doi: 10.1056/NEJM198303313081301.
3
Infection of Syrian hamsters with Lyme disease spirochetes.用莱姆病螺旋体感染叙利亚仓鼠。
J Clin Microbiol. 1984 Dec;20(6):1099-101. doi: 10.1128/jcm.20.6.1099-1101.1984.
4
Human phagocyte interactions with the Lyme disease spirochete.人类吞噬细胞与莱姆病螺旋体的相互作用。
Infect Immun. 1984 Nov;46(2):608-11. doi: 10.1128/iai.46.2.608-611.1984.
5
Phagocytic cell responses to in vivo and in vitro exposure to the Lyme disease spirochete.吞噬细胞对体内和体外暴露于莱姆病螺旋体的反应。
Yale J Biol Med. 1984 Jul-Aug;57(4):599-605.
6
Complement and the host's defense against the pneumococcus.补体与宿主对肺炎球菌的防御
Crit Rev Microbiol. 1984;11(3):187-208. doi: 10.3109/10408418409105903.
7
Interactions of phagocytes with the Lyme disease spirochete: role of the Fc receptor.吞噬细胞与莱姆病螺旋体的相互作用：Fc受体的作用
J Infect Dis. 1984 Oct;150(4):497-507. doi: 10.1093/infdis/150.4.497.
8
The immune response in the hamster. V. Biologic activities of 7S-gamma-1 and 7S-gamma-2 globulins.仓鼠的免疫反应。V. 7S-γ-1和7S-γ-2球蛋白的生物学活性。
J Immunol. 1971 Jul;107(1):76-82.
9
The surgical pathology of human Lyme disease. An enlarging picture.人类莱姆病的外科病理学。一幅不断扩展的图景。
Am J Surg Pathol. 1987;11 Suppl 1:47-60. doi: 10.1097/00000478-198700111-00005.
10
The effect of C3 depletion on resistance of hamsters to infection with the yaws spirochete.C3 缺失对仓鼠抵抗雅司螺旋体感染能力的影响。
Sex Transm Dis. 1986 Oct-Dec;13(4):245-50. doi: 10.1097/00007435-198610000-00007.
Zotero 插件