Fracella F, Rensing L
Institut für Zellbiologie, Biochemie und Biotechnologie der Universität, Bremen.
Naturwissenschaften. 1995 Jul;82(7):303-9.
In response to a variety of "emergencies", cells produce several stress proteins (heat shock proteins, HSP) that provide them with higher resistance and are able to repair protein damage. Their expression is regulated by heat shock transcription factors. Stress proteins are arousing growing interest in medicine, as major antigens in some infections and certain autoimmune diseases and also because of their possible involvement in the development and therapy of cancer. Elevated levels of stress proteins protect tissues and organs against ischemic injury and reduce infarct size. Stress proteins may also serve as a marker in diagnostic studies and in toxicology.
针对各种“紧急情况”，细胞会产生几种应激蛋白（热休克蛋白，HSP），这些蛋白赋予细胞更高的抗性，并能够修复蛋白质损伤。它们的表达受热休克转录因子调控。应激蛋白在医学上引起了越来越多的关注，因为它们是某些感染和特定自身免疫性疾病中的主要抗原，还因为它们可能参与癌症的发生和治疗。应激蛋白水平升高可保护组织和器官免受缺血性损伤，并减小梗死面积。应激蛋白还可作为诊断研究和毒理学中的一个标志物。
