Mannes G P, de Boer W J, van der Bij W
Department of Pulmonary Diseases, University Hospital, Groningen, Netherlands.
Neth J Med. 1995 Jun;46(6):298-305. doi: 10.1016/0300-2977(95)00023-g.
Worldwide more than 600 heart-lung or lung transplantations have been performed in patients with cystic fibrosis and end-stage respiratory disease. At the University Hospital in Groningen 10 patients with cystic fibrosis underwent bilateral sequential lung transplantation until April 1994. The 1-year survival was 76%, which is similar to that of lung transplant recipients with other diseases. Postoperative problems were mainly related to acute rejection, chronic graft dysfunction and infection. The main problem for further extension of the lung transplantation program is the persistent shortage of usable donor-organs for cystic fibrosis patients, especially of small-sized donors.
全球范围内，已对600多名患有囊性纤维化和终末期呼吸系统疾病的患者进行了心肺或肺移植手术。截至1994年4月，格罗宁根大学医院有10名囊性纤维化患者接受了双侧序贯肺移植。1年生存率为76%，这与其他疾病的肺移植受者相似。术后问题主要与急性排斥反应、慢性移植物功能障碍和感染有关。肺移植项目进一步扩大的主要问题是，囊性纤维化患者可用供体器官持续短缺，尤其是小尺寸供体。
