Iacono R P, Lonser R R, Oh A, Yamada S
Department of Surgery, Loma Linda University Medical Center, CA 92350, USA.
Neurol Res. 1995 Jun;17(3):178-80. doi: 10.1080/01616412.1995.11740308.
Since the failure of levodopa therapy to maintain long-term symptom relief in Parkinson's disease, posteroventral pallidotomy has seen a dramatic increase in use and interest. It has significantly reduced both the akinetic and hyperkinetic symptoms of Parkinson's disease while requiring most patients to maintain preoperative levodopa doses. Here we review the clinical results of over 300 posteroventral pallidotomies and pathophysiology of Parkinson's disease in relationship to different neurotransmitters and medical therapy.
由于左旋多巴疗法无法在帕金森病中维持长期症状缓解，后腹侧苍白球切开术的应用和关注度急剧上升。它显著减轻了帕金森病的运动不能和运动亢进症状，同时大多数患者需要维持术前左旋多巴剂量。在此，我们回顾了300多例后腹侧苍白球切开术的临床结果以及帕金森病与不同神经递质和药物治疗相关的病理生理学。
