Seigneur M, Boisseau M, Conri C, Lestage B, Amiral J, Constans J
Laboratoire d'Hématologie, Université de Bordeaux II, France.
Nouv Rev Fr Hematol (1978). 1995;37(2):171-3.
In 34 patients with peripheral occlusive arterial disease, circulating levels of endothelial cell markers were compared with the ischemic status. Unlike tissue plasminogen activator and plasminogen activator inhibitor, plasma levels of thrombomodulin were closely related to both transcutaneous oxygen pressure (p = 0.01) and the graded clinical stages of disease (p = 0.02). Levels of von Willebrand factor were correlated only with the transcutaneous oxygen pressure (p = 0.04). Since thrombomodulin and von Willebrand factor constitute markers of endothelial cell damage, the extent of endothelial injury would appear to be determined by the ischemic status.
在34例外周动脉闭塞性疾病患者中，对内皮细胞标志物的循环水平与缺血状态进行了比较。与组织型纤溶酶原激活物和纤溶酶原激活物抑制剂不同，血栓调节蛋白的血浆水平与经皮氧分压（p = 0.01）和疾病的分级临床阶段均密切相关（p = 0.02）。血管性血友病因子水平仅与经皮氧分压相关（p = 0.04）。由于血栓调节蛋白和血管性血友病因子构成了内皮细胞损伤的标志物，内皮损伤的程度似乎由缺血状态决定。
