Weiner J A, Nylander M
National Board of Occupational Safety and Health, Solna, Sweden.
Sci Total Environ. 1995 Jun 30;168(3):255-65. doi: 10.1016/0048-9697(95)04609-5.
Mercury is released from amalgam fillings in several forms, i.e. as elemental vapour, ions and in fine particles. Despite many investigations there is still considerable uncertainty concerning the uptake of such mercury. Most available estimates have calculated the pulmonary uptake of mercury vapour based on measurements of concentrations intra-orally or in expired breath. Presented estimates vary by an order of magnitude from approximately 1 to 20 micrograms/day. The possibility of estimating this uptake based on levels of mercury in a biological index medium has received comparatively little attention. The purpose of the present work is to estimate the uptake of mercury from amalgam fillings based on urinary concentrations of mercury. It is estimated that the average uptake of mercury from amalgam fillings in Swedish subjects is within the interval 4-19 micrograms/day. This interval was arrived at after a detailed evaluation of the uncertainties in the data used and in the different assumptions. Notwithstanding the considerable range of this estimate it indicates a higher uptake than several other estimates, some of which have had a large impact on the scientific debate concerning this issue.
汞以多种形式从汞合金填充物中释放出来，即元素汞蒸气、离子和细颗粒。尽管进行了许多研究，但关于此类汞的吸收仍存在相当大的不确定性。大多数现有估计是根据口腔内或呼出气体中的浓度测量来计算汞蒸气的肺部吸收量。目前给出的估计值相差一个数量级，约为每天1至20微克。基于生物指标介质中的汞含量来估计这种吸收量的可能性相对较少受到关注。本研究的目的是根据尿汞浓度来估计汞合金填充物中汞的吸收量。据估计，瑞典受试者从汞合金填充物中吸收汞的平均量在每天4至19微克的区间内。这个区间是在对所用数据和不同假设中的不确定性进行详细评估后得出的。尽管这个估计值范围相当大，但它表明的吸收量高于其他一些估计值，其中一些估计值对关于这个问题的科学辩论产生了很大影响。
