Van Duin C T, Wensing T, Van Miert A S
Department of Veterinary Basic Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Vet Res Commun. 1995;19(2):149-57. doi: 10.1007/BF01839281.
The purpose of this study was to assess whether pentoxifylline, a drug that can inhibit the production and action of pro-inflammatory cytokines, had beneficial effects on the acute-phase response to E. coli endotoxin in the dwarf goat. First, the effects of 0.5 mg/kg per min pentoxifylline given intravenously over 15 min were examined in five goats. One week later, the clinical changes caused by i.v. injection of E. coli endotoxin (LPS: 0.1 microgram/kg) were determined. This endotoxin induced fever, tachycardia, inhibition of rumen motility, and decreases in plasma zinc and iron concentrations. Three weeks later, the effect of E. coli LPS were again determined immediately after pentoxifylline infusion in the same group of animals. It was concluded that a pharmacological dose of pentoxifylline has no protective effects on the acute-phase response reactions induced by a pyrogenic dose of E. coli LPS.
本研究的目的是评估己酮可可碱（一种可抑制促炎细胞因子产生和作用的药物）对矮山羊大肠杆菌内毒素急性期反应是否具有有益作用。首先，在五只山羊中检测了以每分钟0.5毫克/千克的剂量静脉注射己酮可可碱15分钟的效果。一周后，确定静脉注射大肠杆菌内毒素（脂多糖：0.1微克/千克）引起的临床变化。这种内毒素可引起发热、心动过速、瘤胃运动抑制以及血浆锌和铁浓度降低。三周后，在同一组动物中输注己酮可可碱后立即再次测定大肠杆菌脂多糖的作用。得出的结论是，药理剂量的己酮可可碱对致热剂量的大肠杆菌脂多糖诱导的急性期反应没有保护作用。
