Van Miert A S, Van Duin C T, Wensing T
Department of Veterinary Basic Sciences Utrecht University, The Netherlands.
Vet Q. 1994 Mar;16(1):1-6. doi: 10.1080/01652176.1994.9694405.
Flurbiprofen, a potent NSAID, was given as an intravenous infusion (1 mg/kg) to dwarf goats. After drug administration, no significant changes were observed in heart rate and rumen motility, whereas rectal temperature increased slightly; mean plasma glucose and creatinine concentrations gradually increased during the observation period. Plasma iron concentration and the number of circulating lymphocytes were significantly lower after flurbiprofen infusion. Intravenous injection of recombinant human interleukin-1 alpha (r. HuIL-1 alpha: 0.5 microgram/kg) caused shivering, fever, inhibition of rumen contractions, tachycardia, hypoferraemia, hypozincaemia, hyperglycaemia followed by hypoglycaemia, changes in plasma urea and creatinine values, lymphopaenia and neutropaenia followed by neutrophilic leukocytosis. Pretreatment with flurbiprofen partly antagonized the febrile reactions to r.HuIL-1 alpha. The r.HuIL-1 alpha-induced tachycardia and inhibition of rumen contractions were only delayed. The drug prevented the initial hyperglycaemia but did not abolish the secondary hypoglycaemia. Furthermore, flurbiprofen delayed the decline in plasma zinc and iron concentrations, whereas plasma creatinine values were significantly lower. Finally, after drug pretreatment the changes in circulating neutrophils were more pronounced. These data demonstrate that most of the haematological, blood biochemical, and clinical effects of r.HuIL-1 alpha cannot be blocked by flurbiprofen, suggesting that an increased synthesis of prostaglandins is not involved in these r.HuIL-1 alpha-induced effects.
氟比洛芬是一种强效非甾体抗炎药，以静脉输注的方式（1毫克/千克）给予侏儒山羊。给药后，心率和瘤胃蠕动未观察到显著变化，而直肠温度略有升高；在观察期内，平均血浆葡萄糖和肌酐浓度逐渐升高。氟比洛芬输注后血浆铁浓度和循环淋巴细胞数量显著降低。静脉注射重组人白细胞介素-1α（r.HuIL-1α：0.5微克/千克）可引起颤抖、发热、瘤胃收缩抑制、心动过速、低铁血症、低锌血症、高血糖随后低血糖、血浆尿素和肌酐值变化、淋巴细胞减少和中性粒细胞减少随后中性粒细胞增多。氟比洛芬预处理可部分拮抗对r.HuIL-1α的发热反应。r.HuIL-1α诱导的心动过速和瘤胃收缩抑制仅被延迟。该药物可预防初始高血糖，但不能消除继发性低血糖。此外，氟比洛芬延迟了血浆锌和铁浓度的下降，而血浆肌酐值显著降低。最后，药物预处理后循环中性粒细胞的变化更为明显。这些数据表明，r.HuIL-1α的大多数血液学、血液生化和临床效应不能被氟比洛芬阻断，这表明前列腺素合成增加不参与这些r.HuIL-1α诱导的效应。
