Yamaguchi S, Jihong L, Utsunomiya M, Yoshioka T, Okuyama A, Koide T, Sugiyama K
Department of Urology, Osaka University School of Medicine.
Hinyokika Kiyo. 1995 Jun;41(6):427-31.
We examined the inhibitory effect of the two Kampo medicines, takusha and kagosou on the formation of calcium oxalate renal stones induced by ethylene glycol (EG) and 1 alpha(OH)D3 (1 alpha-D3) in rats. Wistar strain rats were divided into 4 groups (A: normal control, B: stone, C: kagosou, D: takusya). There was no significant difference in urinary calcium excretion or oxalate excretion between the stone group and kampo medicine groups. The calcium content of the kidneys was significantly lower in the takusha group than in the other two groups (Stone group and kagosou group). Takusha was effective in preventing oxalate stone formation in rats. Kagosou, which had strong inhibitory effect on calcium oxalate crystal growth and aggregation in vitro as well as takusha, was not effective against in vivo calcium oxalate stone formation in rats. These findings suggest that takusha prevents the formation of calcium oxalate stone by inhibiting calcium oxalate crystal growth and aggregation.
我们研究了汉方药拓舒和加古草对乙二醇（EG）和1α（OH）D3（1α-D3）诱导的大鼠草酸钙肾结石形成的抑制作用。将Wistar品系大鼠分为4组（A：正常对照组，B：结石组，C：加古草组，D：拓舒组）。结石组与汉方药组之间的尿钙排泄或草酸排泄无显著差异。拓舒组肾脏的钙含量显著低于其他两组（结石组和加古草组）。拓舒对预防大鼠草酸钙结石形成有效。加古草在体外对草酸钙晶体生长和聚集具有很强的抑制作用，与拓舒一样，但对大鼠体内草酸钙结石形成无效。这些发现表明，拓舒通过抑制草酸钙晶体生长和聚集来预防草酸钙结石的形成。
