Brumen V, Horvat D, Trosić I
Institute for Medical Research and Occupational Health, Zagreb, Croatia.
Am J Ind Med. 1995 Jun;27(6):871-6. doi: 10.1002/ajim.4700270610.
The aim of the study was to evaluate the genotoxic risk to medical personnel concurrently exposed to ionizing radiation and antineoplastics, using changes in their lymphocyte cell genome as a bioindicator. The study comprised 12 female nurses employed in the nuclear medicine hospital department and an equal number of matched controls. For each examinee, both conventional structural chromosomal aberration analysis and sister chromatid exchange test (SCE) were carried out. According to Student's t-test, neither the incidence of structural chromosomal aberrations (p > 0.6) nor the mean SCE-frequency rate (p > 0.3) were significantly increased among the exposed subjects. Nevertheless, in those exposed, irreparable chromosomal damages and wide SCE-ranges were observed. Such findings suggest the possibility of genotoxic implications of concurrent occupational exposure to ionizing radiation and antineoplastic drugs.
本研究的目的是通过医学人员淋巴细胞基因组的变化作为生物指标，评估同时暴露于电离辐射和抗肿瘤药物下的医学人员的遗传毒性风险。该研究包括12名在核医学医院科室工作的女护士以及数量相同的匹配对照组。对每位受试者均进行了常规的结构染色体畸变分析和姐妹染色单体交换试验（SCE）。根据学生t检验，暴露组受试者的结构染色体畸变发生率（p>0.6）和平均SCE频率率（p>0.3）均未显著增加。然而，在暴露者中观察到了不可修复的染色体损伤和较宽的SCE范围。这些发现表明，职业性同时暴露于电离辐射和抗肿瘤药物可能具有遗传毒性影响。
