Benhamou S, Pot-Deprun J, Sancho-Garnier H, Chouroulinkov I
Unité de Recherches en Epidémiologie des Cancers de l'INSERM (U287), Institut Gustave Roussy, Villejuif, France.
Int J Cancer. 1988 Mar 15;41(3):350-3. doi: 10.1002/ijc.2910410305.
A cohort study of 29 nurses who constantly handled cytostatic drugs, and 29 controls matched according to sex and age, was carried out between 1983 and 1986. Cytogenetic damage was assessed by sister chromatid exchanges (SCE) and chromosomal aberrations. No significant increase in mean number of SCE was found for nurses (7.37) as compared to matched controls (7.00), whereas a significant excess of SCE (p less than 0.001) was observed for smokers (8.23) as compared to non-smokers (6.75). The number of SCE was studied in relation to the amount and nature of cytostatics handled as well as to the duration of exposure. A significant association (p less than 0.05) was found between individual mean number of SCE and the total number of drugs handled after adjustment for confounding factors. In contrast, the number of SCE was not significantly related to the nature of drugs handled or to the duration of exposure. With regard to chromosomal damage, no significant difference was observed between nurses and controls in gap, break, dicentric and translocation frequencies.
1983年至1986年间，对29名经常接触细胞毒性药物的护士以及29名按性别和年龄匹配的对照人员进行了一项队列研究。通过姐妹染色单体交换（SCE）和染色体畸变评估细胞遗传学损伤。与匹配的对照组（7.00）相比，未发现护士组（7.37）的SCE平均数有显著增加，而与不吸烟者（6.75）相比，吸烟者（8.23）的SCE显著过量（p小于0.001）。研究了SCE的数量与所接触细胞毒性药物的数量和性质以及接触持续时间的关系。在对混杂因素进行调整后，发现个体SCE平均数与所处理药物的总数之间存在显著关联（p小于0.05）。相比之下，SCE的数量与所处理药物的性质或接触持续时间没有显著关系。关于染色体损伤，在护士和对照组之间，间隙、断裂、双着丝粒和易位频率未观察到显著差异。
