Christie G W, Barratt-Boyes B G
Systematic Solutions Limited and Green Lane Hospital, Auckland, New Zealand.
Ann Thorac Surg. 1995 Aug;60(2 Suppl):S195-9. doi: 10.1016/0003-4975(95)00279-t.
This study measured the biaxial properties of pulmonary and aortic leaflets in extension in the fresh state and then in the same samples after fixation with glutaraldehyde. The results showed that when fresh, the valves had a similar response to load in the circumferential direction, but the pulmonary leaflets were more extensible in the radial direction. They were also less stiff. Fixation decreased the tissue extensibility and increased the stiffness of the pulmonary leaflets much less than in the aortic leaflets. This was interpreted to mean that the collagen content of the pulmonary leaflets is significantly less than that in the aortic leaflets. Reduced collagen content would be expected to enhance hemodynamic performance because of increased leaflet stretch and reduced stiffness. However, lower collagen levels may reduce implant durability.
本研究测量了新鲜状态下以及用戊二醛固定后的相同样本中肺叶瓣和主动脉瓣叶在伸展时的双轴特性。结果表明，新鲜时，瓣膜在圆周方向上对负荷的反应相似，但肺叶瓣在径向方向上更具延展性。它们的硬度也更低。固定后，肺叶瓣的组织延展性降低，硬度增加，但其增加幅度远小于主动脉瓣叶。这被解释为意味着肺叶瓣的胶原蛋白含量明显低于主动脉瓣叶。由于瓣叶伸展增加和硬度降低，胶原蛋白含量减少有望提高血液动力学性能。然而，较低的胶原蛋白水平可能会降低植入物的耐久性。
