抑郁症亚组中安慰剂反应者与无反应者的比较。
A comparison of placebo responders and nonresponders in subgroups of depressive disorder.
作者信息
Bialik R J, Ravindran A V, Bakish D, Lapierre Y D
机构信息
Department of Psychiatry, University of Ottawa, Ontario, Canada.
出版信息
J Psychiatry Neurosci. 1995 Jul;20(4):265-70.
The objective of this study was to determine if the placebo treatment response varied in subgroups of depressed patients (single episode, recurrent, and double depression). Data from placebo-treated patients from seven placebo-controlled clinical trials were pooled and analyzed retrospectively. The placebo response rate was highest for females with a single episode of depression (66.7%) and lowest for females with recurrent depressive episodes (13.3%). Among patients experiencing their first episode, placebo responders had lower Hamilton Rating Scale for Depression (HAMD) total scores at baseline and lower ratings of pschomotor retardation than nonresponders. For patients having a recurrence of an episode, placebo responders had lower baseline ratings of somatic anxiety. The major finding was that patients suffering from their first depressive episode differed from patients with recurrent depressive episodes in the rate of placebo response, effect of gender, and the clinical symptoms that were associated with a positive placebo response.
本研究的目的是确定安慰剂治疗反应在抑郁症患者亚组（单次发作、复发性和双重抑郁症）中是否存在差异。对来自七项安慰剂对照临床试验的接受安慰剂治疗患者的数据进行汇总并进行回顾性分析。单次发作抑郁症女性的安慰剂反应率最高（66.7%），而复发性抑郁发作女性的安慰剂反应率最低（13.3%）。在首次发作的患者中，安慰剂反应者在基线时的汉密尔顿抑郁量表（HAMD）总分较低，且精神运动迟缓评分低于无反应者。对于有发作复发的患者，安慰剂反应者的躯体焦虑基线评分较低。主要发现是，首次抑郁发作的患者与复发性抑郁发作的患者在安慰剂反应率、性别影响以及与阳性安慰剂反应相关的临床症状方面存在差异。
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