Stadler H S, Murray J C, Leysens N J, Goodfellow P J, Solursh M
University of Iowa, Department of Biological Sciences, Iowa City 52242, USA.
Mamm Genome. 1995 Jun;6(6):383-8. doi: 10.1007/BF00355637.
Homeobox genes represent a class of transcription factors that play key roles in the regulation of embryogenesis and development. Here we report the identification of a homeobox-containing gene family that is highly conserved at both the nucleotide and amino acid levels in a diverse number of species. These species encompass both vertebrate and invertebrate phylogenies, ranging from Homo sapiens to Drosophila melanogaster. In humans, at least two homeobox sequences from this family were identified representing a previously reported member of this family as well as a novel homeobox sequence that we physically mapped to the 10q25.2-q26.3 region of human Chromosome (Chr) 10. Multiple members of this family were also detected in three additional vertebrate species including Equus caballus (horse), Gallus gallus (Chicken), and Mus musculus (mouse), whereas only single members were detected in Tripneustes gratilla (sea urchin), Petromyzon marinus (lamprey), Salmo salar (salmon), Ovis aries (sheep), and D. melanogaster (fruit fly).
同源异型盒基因是一类转录因子，在胚胎发生和发育的调控中发挥关键作用。在此，我们报告了一个含有同源异型盒的基因家族的鉴定结果，该家族在众多物种的核苷酸和氨基酸水平上都高度保守。这些物种涵盖了脊椎动物和无脊椎动物的系统发育，从智人到黑腹果蝇。在人类中，鉴定出了该家族的至少两个同源异型盒序列，其中一个代表该家族先前报道的成员，另一个是我们通过物理定位到人类染色体（Chr）10的10q25.2 - q26.3区域的新同源异型盒序列。在另外三种脊椎动物物种中也检测到了该家族的多个成员，包括马（Equus caballus）、鸡（Gallus gallus）和小鼠（Mus musculus），而在海胆（Tripneustes gratilla）、七鳃鳗（Petromyzon marinus）、鲑鱼（Salmo salar）、绵羊（Ovis aries）和黑腹果蝇（D. melanogaster）中仅检测到单个成员。
