[复方四参饮对病毒性心肌炎患者细胞免疫的影响]

[Effect of fu-fang si-shen yin on cellular immunity in patients with viral myocarditis].

作者信息

Wei Q H, Zheng X C, Shi Y Y

机构信息

Shanghai First People's Hospital.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Mar;15(3):144-6.

PMID:7647527

Abstract

In order to study the effect of the Fu-Fang Si-Shen Yin (FFSSY) on cellular immunity, the natural killer (NK) cell activity of 60 patients with viral myocarditis, while the lymphocyte subsets consisted of OKT3, OKT4, OKT8, OKT4/OKT8 of other 20 patients were determined. The pretreatmental results were 25.25 +/- 0.46%, 59.11 +/- 8.72%, 30.72 +/- 6.94%, 29.72 +/- 5.35% and 1.04 +/- 0.24 respectively, which were significantly lower than that of the normal value (P < 0.01) except OKT8 However, after the treatment with FFSSY, NK cell activity and OKT3, OKT4, OKT4/OKT8 were elevated to 30.96 +/- 10.13% (P < 0.05), 62.33 +/- 7.78% (P < 0.05), 33.67 +/- 5.50% (P < 0.05) and 1.14 +/- 0.20 (P < 0.01) respectively. The Syndrome Differentiation of TCM indicated that NK cell activity decreased obviously in the Qi-Yin-Deficiency group, while T lymphocyte subsets changed significantly in the Qi-Deficiency group. There existed negative correlation between NK cell activity and OKT4/OKT8 (r = -0.60, P < 0.05). The patients with high NK cell activity in the early stage could have a favourable prognosis, while unfavourable with low NK cell activity.

摘要

为研究复方四参饮（FFSSY）对细胞免疫的影响，测定了60例病毒性心肌炎患者的自然杀伤（NK）细胞活性，同时测定了另外20例患者的淋巴细胞亚群，包括OKT3、OKT4、OKT8、OKT4/OKT8。治疗前结果分别为25.25±0.46%、59.11±8.72%、30.72±6.94%、29.72±5.35%和1.04±0.24，除OKT8外，均显著低于正常值（P<0.01）。然而，经FFSSY治疗后，NK细胞活性及OKT3、OKT4、OKT4/OKT8分别升高至30.96±10.13%（P<0.05）、62.33±7.78%（P<0.05）、33.67±5.50%（P<0.05）和1.14±0.20（P<0.01）。中医辨证表明，气阴两虚组NK细胞活性明显降低，而气虚组T淋巴细胞亚群变化显著。NK细胞活性与OKT4/OKT8之间存在负相关（r=-0.60，P<0.05）。早期NK细胞活性高的患者预后良好，而NK细胞活性低则预后不良。