Kahaly G, Diaz M, Just M, Beyer J, Lieb W
Department of Endocrinology/Metabolism, Johannes Gutenberg-University Hospital, Mainz, Germany.
Thyroid. 1995 Apr;5(2):107-11. doi: 10.1089/thy.1995.5.107.
Since the identification of somatostatin receptors on lymphocytes, orbital infiltration with mononuclear cells in Graves' ophthalmopathy has provided a rationale for receptor imaging with the radiolabeled somatostatin analog Octreotide. In 40 patients with Graves' ophthalmopathy and 10 controls, 110 MBq indium-Octreotide were administered i.v., and scans were performed at 4 and 24 h after injection. An uptake ratio between the orbits and the brain was determined. In 20 ophthalmophathy patients, magnetic resonance imaging (MRI) of the orbits was performed and the T2 relaxation time was measured within the rectus muscles. Compared to controls (4 h Octreotide uptake: median 6.0 counts/pixel/MBq, orbit/brain ratio 5.6), ophthalmopathy patients showed a 2- to 3-fold increased uptake (15.8 counts/pixel/MBq vs controls p = 0.0032; ratio 12.6, vs controls p = 0.003). When considering patients with active disease only, a higher uptake was registered (16.8 counts/pixel/MBq vs controls p 0.0048, ratio 15.6 vs controls p = 0.0006). Untreated patients showed a markedly higher uptake (23 counts/pixel/MBq) compared to patients receiving steroid therapy (12.6, p = 0.001). MRI of the orbit revealed a correlation between T2 relaxation time of the eye muscles and orbital uptake of Octreotide (p < 0.001).
自从在淋巴细胞上发现生长抑素受体以来，格雷夫斯眼病中单核细胞眼眶浸润为使用放射性标记的生长抑素类似物奥曲肽进行受体显像提供了理论依据。对40例格雷夫斯眼病患者和10例对照者静脉注射110 MBq铟标记的奥曲肽，并在注射后4小时和24小时进行扫描。测定眼眶与脑之间的摄取率。对20例眼病患者进行眼眶磁共振成像（MRI），并测量眼直肌内的T2弛豫时间。与对照组相比（奥曲肽4小时摄取：中位数6.0计数/像素/MBq，眼眶/脑比率5.6），眼病患者的摄取增加了2至3倍（15.8计数/像素/MBq，与对照组相比p = 0.0032；比率12.6，与对照组相比p = 0.003）。仅考虑患有活动性疾病的患者时，摄取更高（16.8计数/像素/MBq，与对照组相比p = 0.0048，比率15.6，与对照组相比p = 0.0006）。未治疗的患者与接受类固醇治疗的患者相比，摄取明显更高（23计数/像素/MBq对12.6，p = 0.001）。眼眶MRI显示眼肌的T2弛豫时间与奥曲肽的眼眶摄取之间存在相关性（p < 0.001）。
