Małlolepszy J, Krasnowska M, Passowicz-Muszyńska E
Katedry i Kliniki Chorób Wewnetrznych i Alergologii AM we Wrocłlawiu.
Pneumonol Alergol Pol. 1995;63(3-4):192-6.
15 patients with mild bronchial asthma were selected for study. They inhaled salbutamol 2.5 mg three times daily for 8 days. Bronchodilator dose-response studies were performed by administering increasing doses of isuprel intravenously before and after treatment with salbutamol. Histamine provocation was done to estimate airway responsiveness. That was performed prior to and after salbutamol therapy. Regular inhaled salbutamol increased airway responsiveness to histamine--Pc20 was significantly reduced from 1.95 mg/ml--before treatment to 0.44 mg/ml--after salbutamol therapy. The bronchodilatory effect after isuprel was the same before and after treatment with salbutamol.
选取15例轻度支气管哮喘患者进行研究。他们每日三次吸入2.5毫克沙丁胺醇，共8天。在用沙丁胺醇治疗前后，通过静脉注射递增剂量的异丙肾上腺素进行支气管扩张剂剂量反应研究。进行组胺激发试验以评估气道反应性。该试验在沙丁胺醇治疗前后进行。规律吸入沙丁胺醇会增加气道对组胺的反应性——组胺激发试验中使组胺浓度下降20%所需的组胺累积剂量（Pc20）从治疗前的1.95毫克/毫升显著降至沙丁胺醇治疗后的0.44毫克/毫升。在用异丙肾上腺素后，支气管扩张效果在沙丁胺醇治疗前后相同。
