Chhabra S K
Department of Cardiorespiratory Physiology, Vallabhabhi Patel Chest Institute, Delhi.
Indian J Chest Dis Allied Sci. 1994 Jul-Sep;36(3):119-24.
Fifteen adults with moderately severe asthma underwent two sequential treatments, first with inhaled salbutamol, 200 micrograms q.i.d. for 2 weeks followed by a combination of salbutamol 200 micrograms and beclomethasone dipropionate (BDP) 100 micrograms q.i.d. for the next 2 weeks. The response was evaluated by symptoms and additional drugs scores during the two treatments and spirometry before and after each treatment. The second phase of treatment resulted in a greater symptomatic improvement and a reduced need for additional drugs. A clinically significant improvement was observed in lung function after the combination treatment. However, as the comparison was limited to only 2 weeks, this duration of treatment was not adequate to correct the spirometric abnormalities. It was concluded that a combination of salbutamol and BDP was superior to salbutamol alone. Treatment with only bronchodilators results in a poor control of asthma and therefore, these should always be combined with inhaled steroids.
15名患有中度严重哮喘的成年人接受了两个连续疗程的治疗，首先吸入沙丁胺醇，每次200微克，每日4次，持续2周，随后在接下来的2周内，吸入沙丁胺醇200微克与二丙酸倍氯米松（BDP）100微克的组合，每日4次。通过两个疗程中的症状和额外药物评分以及每个疗程前后的肺功能测定来评估反应。第二阶段的治疗带来了更显著的症状改善，且对额外药物的需求减少。联合治疗后肺功能有临床显著改善。然而，由于比较仅局限于2周，这个治疗时长不足以纠正肺功能测定的异常。得出的结论是，沙丁胺醇与BDP的组合优于单独使用沙丁胺醇。仅使用支气管扩张剂治疗哮喘控制不佳，因此，这些药物应始终与吸入性类固醇联合使用。
