下丘脑神经元细胞中促性腺激素释放激素（GnRH）基因表达的调控
Regulation of gonadotropin-releasing hormone (GnRH) gene expression in hypothalamic neuronal cells.
作者信息
Wierman M E, Bruder J M, Kepa J K
机构信息
Department of Medicine, University of Colorado Health Science Center, Denver 80220, USA.
出版信息
Cell Mol Neurobiol. 1995 Feb;15(1):79-88. doi: 10.1007/BF02069559.
Abstract
- Gonadotropin-releasing hormone (GnRH) is the hypothalamic releasing factor that controls pituitary gonadotropin subunit gene expression and indirectly gametogenesis and steroidogenesis from the gonad, which results in reproductive competence. 2. GnRH is synthesized in only about 1000 neurons in the hypothalamus and released in an episodic fashion down the median eminence to regulate gonadotropin biosynthesis. 3. Although much is known about the secretory dynamics of GnRH release, little is known about the pretranslational control of GnRH biosynthesis due to lack of appropriate model systems. The recent availability of immortalized neuronal cell lines that produce GnRH allows investigators for the first time to begin to dissect the factors that directly regulate GnRH gene expression. 4. This article reviews the current state of knowledge concerning the mechanisms that direct tissue-specific and peptide hormone control of GnRH biosynthesis.
摘要
- 促性腺激素释放激素（GnRH）是下丘脑释放因子，它控制垂体促性腺激素亚基基因表达，并间接调控性腺的配子发生和类固醇生成，从而产生生殖能力。2. GnRH仅在下丘脑约1000个神经元中合成，并以脉冲形式释放至正中隆起，以调节促性腺激素的生物合成。3. 尽管对GnRH释放的分泌动力学已了解很多，但由于缺乏合适的模型系统，对GnRH生物合成的翻译前控制知之甚少。最近可获得产生GnRH的永生化神经元细胞系，这使研究人员首次能够开始剖析直接调节GnRH基因表达的因素。4. 本文综述了有关直接控制GnRH生物合成的组织特异性和肽类激素机制的当前知识状态。
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