雏鸡视网膜多巴胺与晶状体诱导的屈光不正

Retinal dopamine and lens-induced refractive errors in chicks.

作者信息

Guo S S, Sivak J G, Callender M G, Diehl-Jones B

机构信息

School of Optometry, Department of Biology, University of Waterloo, Ontario, Canada.

出版信息

Curr Eye Res. 1995 May;14(5):385-9. doi: 10.3109/02713689508999936.

DOI:10.3109/02713689508999936

PMID:7648864

Abstract

This study investigated the relationship between retinal dopamine and lens induced refractive errors in chicks by high performance liquid chromatography with ultraviolet detection (HPLC-UV). After two weeks of lens wear, the chick eyes treated with +10D lenses were hyperopic (+8.29 +/- 0.43D), while the eyes treated with -10D lenses were myopic (-11.69 +/- 0.74D). At the same time, in myopic eyes the level of retinal dopamine and its metabolite 3,4-dihydroxy-phenylacetic acid (DOPAC) were reduced compared to control eyes, while in hyperopic eyes the level of retinal dopamine and DOPAC were increased as compared with control eyes. Therefore, retinal dopamine may participate in the development of lens induced refractive errors in chicks.

摘要

本研究通过高效液相色谱-紫外检测法（HPLC-UV），探究了雏鸡视网膜多巴胺与晶状体诱导性屈光不正之间的关系。佩戴晶状体两周后，接受+10D晶状体治疗的雏鸡眼睛出现远视（+8.29±0.43D），而接受-10D晶状体治疗的眼睛出现近视（-11.69±0.74D）。同时，与对照眼相比，近视眼中视网膜多巴胺及其代谢产物3,4-二羟基苯乙酸（DOPAC）的水平降低，而远视眼中视网膜多巴胺和DOPAC的水平与对照眼相比升高。因此，视网膜多巴胺可能参与了雏鸡晶状体诱导性屈光不正的发生发展。