Blum K, Wood R C, Braverman E R, Chen T J, Sheridan P J
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284, USA.
Funct Neurol. 1995 Jan-Feb;10(1):37-44.
The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the meso-limbic circuitry of the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance (alcohol, drug, tobacco and food) seeking behavior. Decades of research indicate that genetics play an important role in vulnerability to severe substance seeking behavior. We propose that variants of the D2 dopamine receptor gene are important common genetic determinants in predicting compulsive disease.
多巴胺能系统，尤其是多巴胺D2受体，在大脑中脑边缘回路的奖赏机制中有着深远的影响。D2多巴胺受体功能障碍会导致异常的物质（酒精、药物、烟草和食物）寻求行为。数十年的研究表明，基因在严重物质寻求行为的易感性中起着重要作用。我们认为，D2多巴胺受体基因的变异是预测强迫性疾病的重要常见基因决定因素。
