作为奖赏缺乏综合征决定因素的D2多巴胺受体基因。
The D2 dopamine receptor gene as a determinant of reward deficiency syndrome.
作者信息
Blum K, Sheridan P J, Wood R C, Braverman E R, Chen T J, Cull J G, Comings D E
机构信息
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284, USA.
出版信息
J R Soc Med. 1996 Jul;89(7):396-400. doi: 10.1177/014107689608900711.
Abstract
The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.
摘要
多巴胺能系统，尤其是多巴胺D2受体，已被证实与大脑的奖赏机制密切相关。D2多巴胺受体功能失调会导致异常的物质寻求行为（酒精、药物、烟草和食物）以及其他相关行为（病理性赌博、妥瑞氏症和注意力缺陷多动障碍）。我们认为，D2多巴胺受体基因的变异是“奖赏缺乏综合征”重要的常见遗传决定因素。
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