夫沙康唑A和B；来自接骨木镰刀菌的新型丘疹菌素类抗真菌抗生素。I. 产生菌的鉴定、发酵及生物活性

Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. I. Identity of the producing organism, fermentation and biological activity.

作者信息

Jackson M, Frost D J, Karwowski J P, Humphrey P E, Dahod S K, Choi W S, Brandt K, Malmberg L H, Rasmussen R R, Scherr M H

机构信息

Abbott Laboratories, Abbott Park, IL 60064, USA.

出版信息

J Antibiot (Tokyo). 1995 Jul;48(7):608-13. doi: 10.7164/antibiotics.48.608.

DOI:10.7164/antibiotics.48.608

PMID:7649856

Abstract

The fuscandins, antifungal agents of the papulacandin class, are produced by a strain of Fusarium sambucinum. Fermentation yielded 60 mg/liter of fusacandin A and minor amounts of fusacandin B. As expected, the fusacandins inhibit (1,3)-beta-glucan synthesis. Fusacandin A is slightly less active than papulacandin B against Candida albicans and, like papulacandin, loses activity in the presence of serum.

摘要

夫沙菌素是一类丘疹霉素类抗真菌剂，由一株接骨木镰刀菌产生。发酵产生了60毫克/升的夫沙菌素A和少量的夫沙菌素B。正如预期的那样，夫沙菌素抑制（1,3）-β-葡聚糖的合成。夫沙菌素A对白色念珠菌的活性略低于丘疹霉素B，并且与丘疹霉素一样，在血清存在下会失去活性。