School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China.
Molecules. 2023 Apr 13;28(8):3424. doi: 10.3390/molecules28083424.
Fungal microbes are important in the creation of new drugs, given their unique genetic and metabolic diversity. As one of the most commonly found fungi in nature, spp. has been well regarded as a prolific source of secondary metabolites (SMs) with diverse chemical structures and a broad spectrum of biological properties. However, little information is available concerning their derived SMs with antimicrobial effects. By extensive literature search and data analysis, as many as 185 antimicrobial natural products as SMs had been discovered from strains by the end of 2022. This review first provides a comprehensive analysis of these substances in terms of various antimicrobial effects, including antibacterial, antifungal, antiviral, and antiparasitic. Future prospects for the efficient discovery of new bioactive SMs from strains are also proposed.
真菌微生物在新药创制中具有重要作用，因为它们具有独特的遗传和代谢多样性。作为自然界中最常见的真菌之一， spp. 被认为是具有多种化学结构和广泛生物活性的次生代谢产物（SMs）的丰富来源。然而，关于其具有抗菌作用的衍生 SMs 的信息却很少。通过广泛的文献检索和数据分析，截至 2022 年底，已经从 菌株中发现了多达 185 种具有抗菌作用的天然产物作为 SMs。本综述首先全面分析了这些物质在各种抗菌作用方面的特性，包括抗细菌、抗真菌、抗病毒和抗寄生虫。还提出了从 菌株中高效发现新生物活性 SMs 的未来展望。
