瓜拉霉素，一种由链霉菌属NK11687菌株产生的新型杀螨剂。II. 结构解析。

Gualamycin, a novel acaricide produced by Streptomyces sp. NK11687. II. Structural elucidation.

作者信息

Tsuchiya K, Kobayashi S, Kurokawa T, Nakagawa T, Shimada N, Nakamura H, Iitaka Y, Kitagawa M, Tatsuta K

机构信息

Applied Microbiology Research Center, Nippon Kayaku Co. Ltd., Saitama, Japan.

出版信息

J Antibiot (Tokyo). 1995 Jul;48(7):630-4. doi: 10.7164/antibiotics.48.630.

DOI:10.7164/antibiotics.48.630

PMID:7649860

Abstract

A novel acaricide, gualamycin was isolated from the culture broth of Streptomyces sp. NK11687. The structure of gualamycin was determined to be (2R,3S,4S)-2-O-[4-O-(2-amino-2-deoxy-beta-D-gulopyranosyl)-alpha-D - galactopyranosyl]-2,3,4-trihydroxy-4-[(2S,3S,4S,5S)-3,4-dihydroxy-5-hydr oxy - methylpyrrolidin-2-yl] butanoic acid by FAB-MS, 1H and 13C NMR, COSY, HMQC, HMBC, IR, X-ray crystallographic analyses and synthetic studies.

摘要

一种新型杀螨剂瓜拉霉素是从链霉菌属NK11687的培养液中分离得到的。通过快原子轰击质谱（FAB-MS）、核磁共振氢谱（1H NMR）、核磁共振碳谱（13C NMR）、化学位移相关谱（COSY）、异核多量子相干谱（HMQC）、异核多键相关谱（HMBC）、红外光谱（IR）、X射线晶体学分析和合成研究，确定瓜拉霉素的结构为(2R,3S,4S)-2-O-[4-O-(2-氨基-2-脱氧-β-D-古洛吡喃糖基)-α-D-吡喃半乳糖基]-2,3,4-三羟基-4-[(2S,3S,4S,5S)-3,4-二羟基-5-羟甲基吡咯烷-2-基]丁酸。