AB3217 - A，一种由普拉特链霉菌菌株产生的新型抗螨物质。

AB3217-A, a novel anti-mite substance produced by a strain of Streptomyces platensis.

作者信息

Kanbe K, Mimura Y, Tamamura T, Yatagai S, Sato Y, Takahashi A, Sato K, Naganawa H, Nakamura H, Takeuchi T

机构信息

Central Research Laboratories, Hokko Chemical Industry Co., Ltd., Kanagawa, Japan.

出版信息

J Antibiot (Tokyo). 1992 Apr;45(4):458-64. doi: 10.7164/antibiotics.45.458.

DOI:10.7164/antibiotics.45.458

PMID:1592678

Abstract

AB3217-A, a novel anti-mite substance, was isolated from the fermentation broth of a streptomycete strain. The strain was isolated from a soil collected at Kita-azumi, Nagano Prefecture, Japan, and identified as Streptomyces platensis AB3217. AB3217-A was purified by Amberlite IR120B, Diaion HP-20 and CM-Sephadex C-25 column chromatographies. The molecular formula was determined as C17H23NO7 by elemental analysis, MS and 13C NMR spectroscopy. The structure of AB3217-A was determined to be (1R,3S,4S,7R,8R,11R,12S,13R)-4,12,13-trihydroxy-8-(4-methoxy phenyl)-6-aza-2,9,14-trioxatricyclo-[9.2.1.0(3,7)]tetradecane by spectroscopic analysis and X-ray crystallographic analysis. The molecule of AB3217-A has unique structure that deacetylanisomycin and beta-D-xylofuranose linked through glycosidic bond and ether bond resulting in the formation of nine-membered ring. AB3217-A showed marked activity against the two spotted spider mite, Tetranychus urticae.

摘要

AB3217 - A是一种新型抗螨物质，从链霉菌菌株的发酵液中分离得到。该菌株从日本长野县北安昙采集的土壤中分离出来，被鉴定为普拉特链霉菌AB3217。AB3217 - A通过Amberlite IR120B、Diaion HP - 20和CM - Sephadex C - 25柱色谱法进行纯化。通过元素分析、质谱和13C核磁共振光谱确定其分子式为C17H23NO7。通过光谱分析和X射线晶体学分析确定AB3217 - A的结构为(1R,3S,4S,7R,8R,11R,12S,13R)-4,12,13 - 三羟基 - 8 - (4 - 甲氧基苯基)-6 - 氮杂 - 2,9,14 - 三氧杂三环 - [9.2.1.0(3,7)]十四烷。AB3217 - A分子具有独特的结构，脱乙酰茴香霉素和β - D - 木糖呋喃糖通过糖苷键和醚键相连，形成九元环。AB3217 - A对二斑叶螨表现出显著活性。