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Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus.

作者信息

Kakeya H, Takahashi I, Okada G, Isono K, Osada H

出版信息

J Antibiot (Tokyo). 1995 Jul;48(7):733-5. doi: 10.7164/antibiotics.48.733.

DOI:10.7164/antibiotics.48.733
PMID:7649877
Abstract
摘要

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Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus.埃坡拉他汀,一种由海洋真菌产生的、对人神经母细胞瘤细胞有新的促神经突生长作用的化合物。
J Antibiot (Tokyo). 1995 Jul;48(7):733-5. doi: 10.7164/antibiotics.48.733.
2
Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, selectively inhibits the activities of mammalian DNA polymerases and human DNA topoisomerase II.表乳杆菌素,一种在人神经母细胞瘤细胞中发现的新型神经突生长诱导化合物,可选择性抑制哺乳动物DNA聚合酶和人DNA拓扑异构酶II的活性。
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3
A novel lipid compound, epolactaene, induces apoptosis: its action is modulated by its side chain structure.一种新型脂质化合物,表乳链菌素,可诱导细胞凋亡:其作用受其侧链结构调节。
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Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation.荧光和生物素化表乳链菌素衍生物的合成与应用:表乳链菌素及其衍生物诱导二硫键形成。
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Structure-activity relationships of epolactaene analogs as DNA polymerases inhibitors.表霉素类似物作为DNA聚合酶抑制剂的构效关系
Bioorg Med Chem. 2004 May 1;12(9):1983-9. doi: 10.1016/j.bmc.2004.03.007.
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Apoptosis-inducing effect of epolactaene derivatives on BALL-1 cells.表乳链菌素衍生物对BALL-1细胞的凋亡诱导作用。
Bioorg Med Chem. 2006 Apr 1;14(7):2151-61. doi: 10.1016/j.bmc.2005.10.057. Epub 2005 Nov 18.
7
Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factor receptors.表内酯衍生物对缺乏高亲和力神经生长因子受体的人神经母细胞瘤细胞的神经生成作用。
J Med Chem. 1997 Feb 14;40(4):391-4. doi: 10.1021/jm960719a.
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Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity.埃坡霉素衍生物的构效关系:抑制Hsp60伴侣蛋白活性的结构要求
Bioorg Med Chem Lett. 2004 Sep 6;14(17):4425-9. doi: 10.1016/j.bmcl.2004.06.054.
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Chinikomycins A and B: isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp. isolate M045.奇尼霉素A和B:从海洋链霉菌属菌株M045中分离新型抗生素、阐明其结构并研究其生物活性
J Nat Prod. 2005 Mar;68(3):349-53. doi: 10.1021/np030518r.
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Structural analysis of epolactaene derivatives as DNA polymerase inhibitors and anti-inflammatory compounds.埃坡拉内酯衍生物作为DNA聚合酶抑制剂和抗炎化合物的结构分析
Int J Mol Med. 2005 May;15(5):785-93.

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