奇尼霉素A和B：从海洋链霉菌属菌株M045中分离新型抗生素、阐明其结构并研究其生物活性

Chinikomycins A and B: isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp. isolate M045.

作者信息

Li Fuchao, Maskey Rajendra P, Qin Song, Sattler Isabel, Fiebig Heinz H, Maier Armin, Zeeck Axel, Laatsch Hartmut

机构信息

Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.

出版信息

J Nat Prod. 2005 Mar;68(3):349-53. doi: 10.1021/np030518r.

DOI:10.1021/np030518r

PMID:15787434

Abstract

In our screening of marine Streptomycetes for bioactive principles, two novel antitumor antibiotics designated as chinikomycins A (2a) and B (2b) were isolated together with manumycin A (1), and their structures were elucidated by a detailed interpretation of their spectra. Chinikomycins A (2a) and B (2b) are chlorine-containing aromatized manumycin derivatives of the type 64-pABA-2 with an unusual para orientation of the side chains. They exhibited antitumor activity against different human cancer cell lines, but were inactive in antiviral, antimicrobial, and phytotoxicity tests.

摘要

在我们对海洋链霉菌进行生物活性成分筛选的过程中，分离出了两种新型抗肿瘤抗生素，分别命名为奇尼霉素A（2a）和B（2b），同时还分离出了马努霉素A（1），并通过对其光谱的详细解析阐明了它们的结构。奇尼霉素A（2a）和B（2b）是含氯的芳构化马努霉素衍生物，属于64-pABA-2类型，侧链具有不寻常的对位取向。它们对不同的人类癌细胞系表现出抗肿瘤活性，但在抗病毒、抗菌和植物毒性测试中无活性。