Xeno Rasmusson D, Brandt J
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287-7218, USA.
J Clin Exp Neuropsychol. 1995 May;17(3):449-58. doi: 10.1080/01688639508405136.
Patients with probable Alzheimer's disease (AD) were assessed neuropsychologically three times, at 6-month intervals, to identify those with patterns of performance suggesting hemispheric asymmetry in cerebral degeneration. By two different methods, over half of the patients satisfied liberal criteria for cognitive asymmetry on one or more assessments, but only 12-15% did so on all three visits. This is the proportion expected by chance. The small, stable Low Verbal and Low Spatial groups did not differ from each other, nor from the globally impaired group, on clinical or demographic variables. The Low Spatial patients identified by either method had the earliest age of onset and had shorter durations of illness. Limited autopsy data suggest that AD patients with cognitive asymmetries are more likely to have brain pathology in addition to that typical of AD.
对可能患有阿尔茨海默病（AD）的患者每隔6个月进行3次神经心理学评估，以识别出那些表现模式提示大脑变性存在半球不对称的患者。通过两种不同方法，超过半数患者在一次或多次评估中符合认知不对称的宽松标准，但在所有三次就诊中符合该标准的仅为12% - 15%。这是随机预期的比例。小型、稳定的低语言能力组和低空间能力组在临床或人口统计学变量方面彼此之间以及与整体受损组均无差异。通过任何一种方法识别出的低空间能力患者发病年龄最早且病程较短。有限的尸检数据表明，除典型的AD病变外，存在认知不对称的AD患者更有可能出现脑部病变。
