Mackey M A, Conway A J, Handelsman D J
Andrology Unit, Royal Prince Alfred Hospital, Sydney NSW, Australia.
Hum Reprod. 1995 Apr;10(4):862-5. doi: 10.1093/oxfordjournals.humrep.a136051.
We undertook a prospective survey of the tolerability of deep i.m. injections of testosterone enanthate in a castor oil vehicle, the most widely used form of androgen replacement therapy. Over a period of 8 months, 26 men received 551 weekly injections into the gluteal, deltoid or thigh muscle and side-effects were recorded immediately and 1 week after each injection by the same nurse using a standardized questionnaire. Most injections caused no complaints [389/551, 70.6% (95% confidence interval 66.6-74.4%)] but minor local side-effects, mostly pain and bleeding, were common [162/551, 29.4% (25.6-33.4%)]; no serious side-effects were observed. Considering all side-effects, the gluteal site had fewer complaints and was less prone to bleeding but was painful more often than deltoid or thigh injection sites. The laterality of injection at any site had no significant effect on side-effects. The only systemic side-effect was episodes of sudden-onset, non-productive cough associated with faintness following eight injections [1.5% (0.6-2.9%)] which we speculate may have been due to pulmonary oil microembolism. We conclude that, when administered by an experienced nurse, deep i.m. injection of testosterone enanthate in a castor oil vehicle is generally safe and well tolerated but causes relatively frequent minor side-effects, including pain and bleeding. An improved depot form of testosterone would be highly desirable for androgen replacement therapy and hormonal male contraception.
我们对在蓖麻油载体中深部肌内注射庚酸睾酮的耐受性进行了一项前瞻性调查，庚酸睾酮是最广泛使用的雄激素替代疗法形式。在8个月的时间里，26名男性接受了551次每周一次的臀肌、三角肌或大腿肌注射，由同一名护士使用标准化问卷在每次注射后立即和1周后记录副作用。大多数注射没有引起不适[389/551，70.6%（95%置信区间66.6 - 74.4%）]，但轻微的局部副作用很常见，主要是疼痛和出血[162/551，29.4%（25.6 - 33.4%）]；未观察到严重副作用。考虑到所有副作用，臀肌注射部位的不适较少，出血倾向较小，但比三角肌或大腿注射部位更常引起疼痛。任何部位注射的左右侧对副作用没有显著影响。唯一的全身副作用是8次注射后出现的突发性干咳伴头晕发作[1.5%（0.6 - 2.9%）]，我们推测这可能是由于肺油微栓塞所致。我们得出结论，由经验丰富的护士进行深部肌内注射时，在蓖麻油载体中注射庚酸睾酮通常是安全且耐受性良好的，但会引起相对频繁的轻微副作用，包括疼痛和出血。对于雄激素替代疗法和激素男性避孕来说，一种改进的长效睾酮制剂将非常理想。
