人胎盘的免疫学研究。基质内皮细胞对复合免疫球蛋白的结合。
Immunological studies of human placentae. Binding of complexed immunoglobulin by stromal endothelial cells.
作者信息
Johnson P M, Trenchev P, Faulk W P
出版信息
Clin Exp Immunol. 1975 Oct;22(1):133-8.
Abstract
Endothelial cells of foetal stem vessels in cryostat sections of normal, full-term human placentae bind fluorescein-conjugated heat-aggregated human IgG. Soluble immune complexes of sheep anti-human albumin also bind in a pattern that is similar to that of aggregated human IgG, but native human IgG is not bound by placental endothelial cells. Aggregated IgG binding, unlike soluble immune complexes, is blocked by pretreatment of the sections with antiserum to human IgM. Cross-blocking experiments with aggregated IgG and immune complexes suggest that they may be bound by different receptors.
摘要
在正常足月人胎盘的冷冻切片中，胎儿主干血管的内皮细胞可结合荧光素偶联的热聚集人IgG。羊抗人白蛋白的可溶性免疫复合物也以与聚集人IgG相似的模式结合，但天然人IgG不被胎盘内皮细胞结合。与可溶性免疫复合物不同，聚集IgG的结合可被用人IgM抗血清预处理切片所阻断。用聚集IgG和免疫复合物进行的交叉阻断实验表明，它们可能由不同的受体结合。
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