Franks P J, Bosanquet N, Connolly M, Oldroyd M I, Moffatt C J, Greenhalgh R M, McCollum C N
Department of Surgery, Charing Cross and Westminster Medical School, London.
J Epidemiol Community Health. 1995 Aug;49(4):385-8. doi: 10.1136/jech.49.4.385.
To determine which social and clinical factors are associated with healing in patients with venous ulceration.
Patients were questioned about social factors at their first visit to a community ulcer clinic. They were treated by high compression bandage system and were interviewed again after 12 weeks.
Community leg ulcer clinics held in health centres throughout Riverside Health Authority in London.
All patients referred to five community leg ulcer clinics with venous ulceration over a six month period.
These were factors significantly associated with healing within 12 weeks of beginning treatment, measured by odds ratio (OR) given by logistic regression analysis.
Of 168 patients with venous ulceration, 87 (52%) healed after 12 weeks of treatment. Univariate analysis showed that low social class (OR = 3.44, 95% CI 1.17, 10.14), lack of central heating (OR = 2.22, 95% CI 1.18, 4.18), and being single (OR = 2.77, 95% CI 1.15, 6.69) were all significantly associated with delayed healing. After adjustment for the known risk factors of ulcer size, ulcer duration, and general mobility only lack of central heating was still significant (OR = 2.27, 95% CI 1.11, 4.55). The remaining factors failing to achieve statistical significance because of their inter-relationship with the known risk factors.
Clinical features of the ulcer seem to determine the progress of healing in patients with leg ulceration. Although there were associations between socio-economic factors and poor healing, adjustment for clinical risk factors generally led to lower non-significant associations. Only lack of central heating retained its association and may play a part in prolonging healing of venous ulceration.
确定哪些社会和临床因素与静脉性溃疡患者的伤口愈合相关。
患者在首次就诊社区溃疡诊所时接受有关社会因素的询问。他们接受高压力绷带系统治疗,并在12周后再次接受访谈。
伦敦里弗赛德卫生局下属各健康中心开设的社区腿部溃疡诊所。
六个月内转诊至五家社区腿部溃疡诊所的所有静脉性溃疡患者。
这些是与开始治疗12周内愈合显著相关的因素,通过逻辑回归分析得出的比值比(OR)来衡量。
168例静脉性溃疡患者中,87例(52%)在治疗12周后愈合。单因素分析显示,社会阶层低(OR = 3.44,95%可信区间1.17, 10.14)、缺乏中央供暖(OR = 2.22,95%可信区间1.18, 4.18)以及单身(OR = 2.77,95%可信区间1.15, 6.69)均与愈合延迟显著相关。在对溃疡大小、溃疡持续时间和总体活动能力等已知风险因素进行调整后,只有缺乏中央供暖仍然显著相关(OR = 2.27,95%可信区间1.11, 4.55)。其余因素由于与已知风险因素存在相互关系而未达到统计学显著性。
溃疡的临床特征似乎决定了腿部溃疡患者的愈合进程。尽管社会经济因素与愈合不良之间存在关联,但对临床风险因素进行调整后,一般会使不显著的关联降低。只有缺乏中央供暖仍保持其关联性,可能在延长静脉性溃疡的愈合时间方面起作用。