Skene A I, Smith J M, Doré C J, Charlett A, Lewis J D
Department of Vascular Surgery, Northwick Park Hospital, Harrow, Middlesex.
BMJ. 1992 Nov 7;305(6862):1119-21. doi: 10.1136/bmj.305.6862.1119.
To evaluate the prognostic factors in uncomplicated venous leg ulcer healing.
Randomised parallel group controlled trial with subjects stratified by initial ulcer diameter and four months' maximum duration of follow up.
Assessment at Northwick Park Hospital vascular unit with community based treatment.
200 patients with clinical and objective evidence of uncomplicated venous leg ulceration and an initial ulcer diameter > 2 cm.
Time to complete healing of the ulcer.
In the presence of graduated compression healing occurred more rapidly in patients with a smaller initial ulcer area (relative risk of healing 1.92 associated with halving of ulcer area (95% confidence interval 1.58 to 2.33)), shorter duration of ulceration (relative risk 1.35 associated with halving duration (1.17 to 1.56)), younger age (relative risk 1.34 associated with 10 year decrease (1.12 to 1.59)), and no deep vein involvement (relative risk 1.8 (1.19 to 2.78)).
These prognostic factors used in a simple scoring system predict time to healing.
评估单纯性下肢静脉溃疡愈合的预后因素。
随机平行组对照试验，根据初始溃疡直径对受试者进行分层，并进行为期四个月的最长随访。
在诺斯威克公园医院血管科进行评估，并在社区进行治疗。
200例有单纯性下肢静脉溃疡临床及客观证据且初始溃疡直径>2 cm的患者。
溃疡完全愈合的时间。
在采用分级加压治疗的情况下，初始溃疡面积较小的患者愈合更快（溃疡面积减半时愈合的相对风险为1.92（95%置信区间为1.58至2.33）），溃疡持续时间较短（持续时间减半时相对风险为1.35（1.17至1.56）），年龄较轻（年龄每降低10岁相对风险为1.34（1.12至1.59）），且无深静脉受累（相对风险为1.8（1.19至2.78））。
这些预后因素用于简单评分系统可预测愈合时间。
