p59fynT参与白细胞介素-5受体信号传导。
Involvement of p59fynT in interleukin-5 receptor signaling.
作者信息
Appleby M W, Kerner J D, Chien S, Maliszewski C R, Bondada S, Perlmutter R M, Bondadaa S [corrected to Bondada S ]
机构信息
Howard Hughes Medical Institute, Seattle, Washington 98195, USA.
出版信息
J Exp Med. 1995 Sep 1;182(3):811-20. doi: 10.1084/jem.182.3.811.
Abstract
Previous studies implicate the nonreceptor protein tyrosine kinase (PTK) p59fyn in the propagation of signals from the B cell antigen receptor. To elucidate the functions of this kinase, we examined B cell responsiveness in mice engineered to lack the hematopoietic isoform of p59fyn. Remarkably, antigen receptor signaling was only modestly defective in fynTnull B cells. In contrast, signaling from the interleukin (IL)-5 receptor which ordinarily provides a comitogenic stimulus with antiimmunoglobulin, was completely blocked. Our results document the importance of p59fynT in IL-5 responses in B cells, and they support a general model for cytokine receptor signal transduction involving the simultaneous recruitment of at least three families of PTK.
摘要
先前的研究表明，非受体蛋白酪氨酸激酶（PTK）p59fyn参与了B细胞抗原受体信号的传导。为了阐明这种激酶的功能，我们检测了经基因工程改造而缺乏p59fyn造血异构体的小鼠的B细胞反应性。值得注意的是，抗原受体信号传导在fynT基因敲除的B细胞中仅有轻微缺陷。相比之下，白细胞介素（IL）-5受体的信号传导（该信号传导通常与抗免疫球蛋白一起提供协同刺激）则被完全阻断。我们的结果证明了p59fynT在B细胞IL-5反应中的重要性，并且支持了一种涉及至少同时募集三个PTK家族的细胞因子受体信号转导的通用模型。
相似文献
1
Involvement of p59fynT in interleukin-5 receptor signaling.p59fynT参与白细胞介素-5受体信号传导。
J Exp Med. 1995 Sep 1;182(3):811-20. doi: 10.1084/jem.182.3.811.
2
Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn.缺乏p59fyn胸腺异构体的小鼠中T细胞受体信号传导缺陷。
Cell. 1992 Sep 4;70(5):751-63. doi: 10.1016/0092-8674(92)90309-z.
3
4
5
Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.src相关酪氨酸蛋白激酶p59fyn的同工型对T细胞抗原反应性的差异调节
J Exp Med. 1992 Jun 1;175(6):1483-92. doi: 10.1084/jem.175.6.1483.
6
Defective IL-5-receptor-mediated signaling in B cells of X-linked immunodeficient mice.
Int Immunol. 1995 Jan;7(1):21-30. doi: 10.1093/intimm/7.1.21.
7
Interleukin 7 receptor functions by recruiting the tyrosine kinase p59fyn through a segment of its cytoplasmic tail.白细胞介素7受体通过其细胞质尾部的一段区域募集酪氨酸激酶p59fyn发挥作用。
Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12083-7. doi: 10.1073/pnas.89.24.12083.
8
Interleukin-5: an overview.白细胞介素-5：概述
Cancer Treat Res. 1995;80:187-208. doi: 10.1007/978-1-4613-1241-3_7.
9
The role of tyrosine protein phosphorylation in lymphocyte activation.酪氨酸蛋白磷酸化在淋巴细胞激活中的作用。
Annu Rev Cell Biol. 1991;7:257-74. doi: 10.1146/annurev.cb.07.110191.001353.
10
IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.白细胞介素-5受体介导的含SH2/SH3蛋白的酪氨酸磷酸化以及布鲁顿酪氨酸激酶和Janus 2激酶的激活。
J Exp Med. 1994 Dec 1;180(6):2101-11. doi: 10.1084/jem.180.6.2101.
引用本文的文献
1
Fyn kinase is required for optimal humoral responses.Fyn 激酶对于最佳的体液免疫应答是必需的。
PLoS One. 2013 Apr 8;8(4):e60640. doi: 10.1371/journal.pone.0060640. Print 2013.
2
Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1).Fyn 与 T 细胞免疫球蛋白和黏蛋白结构域 1（Tim-1）结合并使其磷酸化。
Mol Immunol. 2011 Jul;48(12-13):1424-31. doi: 10.1016/j.molimm.2011.03.023. Epub 2011 Apr 21.
3
Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils.趋化因子诱导的 Ras-ERK 和 PI3K-Akt 信号通路以及白三烯 C4 的释放依赖于 IL-5 和 IL-3 预刺激的人血嗜酸性粒细胞中的酪氨酸激酶 Lyn。
J Immunol. 2011 Jan 1;186(1):516-26. doi: 10.4049/jimmunol.1000955. Epub 2010 Nov 24.
4
Interleukin-5 regulates genes involved in B-cell terminal maturation.白细胞介素-5调节参与B细胞终末成熟的基因。
Immunology. 2006 Aug;118(4):497-508. doi: 10.1111/j.1365-2567.2006.02382.x.
5
Interleukin-6-induced proliferation of human myeloma cells associated with CD45 molecules.白细胞介素-6诱导的与CD45分子相关的人骨髓瘤细胞增殖。
Int J Hematol. 2003 Aug;78(2):95-105. doi: 10.1007/BF02983376.
6
Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1.Myc拮抗剂和转录抑制因子Mad1对T淋巴细胞发育、生长及细胞大小的调控
EMBO J. 2002 Sep 16;21(18):4820-30. doi: 10.1093/emboj/cdf492.
7
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.一种用于分析依赖布鲁顿酪氨酸激酶的小鼠B淋巴细胞信号转导途径的敏感遗传系统。
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6687-92. doi: 10.1073/pnas.110146697.
8
The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation.B细胞特异性Src家族激酶Blk对于B细胞的发育和激活并非必需。
Mol Cell Biol. 2000 Feb;20(4):1227-33. doi: 10.1128/MCB.20.4.1227-1233.2000.
9
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.Btk和Lyn在B细胞和髓系信号通路中的独立且相反的作用。
J Exp Med. 1998 Sep 7;188(5):833-44. doi: 10.1084/jem.188.5.833.
10
Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation.Lyn激酶、Jak2激酶和Raf-1激酶对于白细胞介素5的抗凋亡作用至关重要，而只有Raf-1激酶对嗜酸性粒细胞的激活和脱颗粒是必不可少的。
J Exp Med. 1998 Aug 3;188(3):421-9. doi: 10.1084/jem.188.3.421.
本文引用的文献
1
Origin of murine B cell lineages.小鼠B细胞谱系的起源。
Annu Rev Immunol. 1993;11:501-38. doi: 10.1146/annurev.iy.11.040193.002441.
2
Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.p56lck与白细胞介素-2受体β链的结合对于白细胞介素-2诱导的p56lck激活至关重要。
EMBO J. 1993 Feb;12(2):759-68. doi: 10.1002/j.1460-2075.1993.tb05710.x.
3
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.人类X连锁无丙种球蛋白血症中B细胞胞质酪氨酸激酶的表达缺陷
Cell. 1993 Jan 29;72(2):279-90. doi: 10.1016/0092-8674(93)90667-f.
4
5
The biology of interleukin-5 and its receptor.白细胞介素-5及其受体的生物学特性
Cancer Invest. 1993;11(5):624-34. doi: 10.3109/07357909309011681.
6
7
Differential regulation of surface immunoglobulin and Lyb2 mediated B cell activation: II. cAMP dependent (prostaglandin E2) and independent (IFN-gamma) mechanisms of regulation of B lymphocyte activation.表面免疫球蛋白和Lyb2介导的B细胞活化的差异调节：II. B淋巴细胞活化调节的cAMP依赖性（前列腺素E2）和非依赖性（干扰素-γ）机制
Int Immunol. 1993 Aug;5(8):949-56. doi: 10.1093/intimm/5.8.949.
8
Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.Src家族蛋白酪氨酸激酶p55blk、p59fyn和p56lyn上与效应分子磷脂酶C-γ2、微管相关蛋白激酶、GTP酶激活蛋白及磷脂酰肌醇3-激酶相互作用的位点定位。
Mol Cell Biol. 1993 Sep;13(9):5877-87. doi: 10.1128/mcb.13.9.5877-5887.1993.
9
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases.与X连锁无丙种球蛋白血症相关的基因是蛋白质酪氨酸激酶src家族的成员。
Nature. 1993 Jan 21;361(6409):226-33. doi: 10.1038/361226a0.
10
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice.免疫缺陷XID小鼠中布鲁顿酪氨酸激酶独特区域的突变
Science. 1993 Jul 16;261(5119):358-61. doi: 10.1126/science.8332901.
Zotero 插件