Mahanty S, Nutman T B
Clinical Parasitology Section, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland.
Cancer Invest. 1993;11(5):624-34. doi: 10.3109/07357909309011681.
IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infections with tissue-dwelling parasites and a diverse group of hypereosinophilic conditions of no known etiology. Our understanding of the biological role of IL-5 in the regulation of Ig production and the development of immunity to parasites is far from complete, but basic knowledge of its action at the cellular level is accumulating and will be critical for the intelligent application of immunotherapy with IL-5 or antibodies to IL-5 in infectious, neoplastic, and possibly other diseases.
白细胞介素-5主要是一种由T细胞产生的细胞因子，对嗜酸性粒细胞以及（在小鼠中）对分泌抗体的B细胞具有多种调节功能。细胞因子的复杂网络似乎控制着白细胞介素-5基因的转录及其产生。这种细胞因子水平异常升高与组织内寄生虫感染以及多种病因不明的高嗜酸性粒细胞增多症有关。我们对白细胞介素-5在免疫球蛋白产生调节和寄生虫免疫发育中的生物学作用的理解还远未完善，但关于其在细胞水平作用的基础知识正在积累，这对于在感染性、肿瘤性以及可能的其他疾病中明智地应用白细胞介素-5或抗白细胞介素-5抗体进行免疫治疗至关重要。
